Varian, Inc.

Atholl Gibson

Weston A Anderson

Peter C Lukens

In some embodiments, a nuclear magnetic resonance (NMR) method comprises generating an indicator of an anticipated time-averaged power for a radio-frequency (RF) pulse set, and anticipatively adjusting a cooling supplied by a cryogenic cooling fluid to an RF coil according to the indicator of the anticipated time-averaged power. The cryogenic cooling adjustment may be performed using a cryogenic fluid heater and/or a mass flow controller disposed in the cryogenic fluid path. The time difference between the start of the cooling adjustment and the start of the RF pulse set is set to be equal to the difference in timescales between the cooling effect of the cooling adjustment and the heating effect of the RF pulse set on the RF coil.

Anticipative temperature regulation of cryogenic NMR probes

Enhanced nuclear polarization of a magnetic resonance sample provides greater detection sensitivity over conventional NMR spectroscopy due to a method and an apparatus of increasing the detection sensitivity. Molecules capable of forming photo-excited triplet states are combined in a solution with a NMR sample. While in a uniform magnetic field the solution is frozen, optical radiation is applied to produce photo-excited triplet states molecules and a microwave radiation is applied to stimulate transitions of one of the triplet lines producing dynamic polarization of the nuclei in the magnetic resonance sample. The frozen sample is then rapidly melted and a NMR analysis is performed.

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Walnut Creek, CA, United States of America

Atholl Gibson