Tohoku University

The University of Tokyo

Yamasa Corporation

Asuka Inoue

Sho Nakamura

Yuko Otani

Junken Aoki

Tomohiko Ohwada

Sejin Jung

Masaya Ikubo

Kumiko Makide

Motoki Hoshina

Atsushi Kawasaki

Kouki Kawakami

Aoki Junken

Provided herein is a method and kit that accurately measure autoantibody activity against a TSH receptor without pretreating a blood sample. The autoantibody activity against a TSH receptor in a blood sample is measured by using a kit for measurement of autoantibody activity against a TSH receptor in a mammal cell, comprising a mammal cell expressing both a cAMP biosensor and the TSH receptor, and a substrate capable of visualizing and/or quantifying the CAMP biosensor as constituents, and performing the steps of: (a) incubating a mammal cell expressing both a cAMP biosensor and the TSH receptor in the presence of a blood sample collected from a test subject; (b) measuring an activation level of the CAMP biosensor after the step (a); and (c) comparing the activation level measured in the step (b) with an activation level in a control to calculate the autoantibody activity.

Method and kit for rapid measurement of autoantibody activity with respect to TSH receptor

The object of the present invention is to provide a compound having a lysophosphatidylserine receptor function modulation activity or a salt thereof. A compound having a lysophosphatidylserine receptor function modulation activity or a salt thereof, or a pharmaceutical composition or a lysophosphatidylserine receptor function moderator containing such compound or salt is provided by the present invention.

Compound having lysophosphatidylserine receptor function modulation activity

Growing community of inventors

Miyagi, Japan

Asuka Inoue