Mayo Foundation for Medical Education and Research

Roche Molecular Systems, Inc.

Hoffmann-la Roche Inc.

Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Astrid Reiser

Franklin R Cockerill, Iii

James R Uhl

Christian Aichinger

Dieter Heindl

Kay-Gunnar Stubenrauch

Waltraud Ankenbauer

Gregor Sagner

Rudolf Vogel

Frank Laue

Karim Tabiti

Gudrun Schmitz-Agheguian

Christine Ebenbichler

Mirko Ritter

Vitaly Svetlichny

Elizaveta Bonch-Osmolovskaya

Bernhard Angerer

Markus Zadak

Ursula Markau

Janis Brockhaus

Alexander Hauber

Martina Junius

Franklin R Cockerill

The present invention relates to in vitro methods for determining the presence or absence of an anti-drug antibody (ADA) or drug/ADA immunecomplexes in a minipig sample. The invention further relates to antibodies specifically binding to minipig IgG that are applicable in the methods of the invention.

Method for determining anti-drug antibodies in a minipig sample

The present invention relates to methods of detecting the presence or absence of methicillin-resistant(MRSA) in a sample, the method comprising performing an amplifying step, a hybridizing step and a detecting step. Furthermore, the present invention relates to primers, probes and kits for the detection of MRSA.

[object Object]

The invention provides methods to detect group B(GBS) in biological samples using real-time PCR. Primers and probes for the detection of GBS are provided by the invention. Articles of manufacture containing such primers and probes for detecting GBS are further provided by the invention.

The invention is directed to an oligonucleotide comprising a molecular rod, wherein preferentially the molecular rod covalently connects the 3' end of a first nucleotide residue with the 5&#x2032; end of a second nucleotide residue. Such oligonucleotides are highly advantageous for real time PCR melting curve analysis.

Oligonucleotides containing molecular rods

The invention provides methods to detect group B streptococcus (GBS) in biological samples using real-time PCR. Primers and probes for the detection of GBS are provided by the invention. Articles of manufacture containing such primers and probes for detecting GBS are further provided by the invention.

Detection of group B streptococcus

A DNA polymerase from a thermophilic eubacterium is provided. The DNA polymerase shows magnesium ion dependent reverse transcriptase activity and 3&prime;-5&prime; exonuclease activity. The invention also includes recombinant plasmids and transformed host cells capable of producing the enzyme. The enzyme is classified into class EC 2.7.7.7., a DNA nucleotidyl transferase DNA-directed type.

Thermostable DNA polymerase from carboxydothermus hydrogenoformans

Growing community of inventors

Antdorf, Germany

Astrid Reiser