King Saud University

Other

Assem Barakat

Mohammad Shahidul Islam

Abdullah Mohammed Al Majid

Muhammad Iqbal Choudhary

Sammer Yousuf

Hazem Ahmed Ghabbour

Hussain Mansur Ghawas

Fardous F El-Senduny

Farid A Badria

Yaseen Ali Mosa Mohamed Elshaier

Abdullah Mohammed Al-Majid

Mohamed Ali

Eman Ahmed Ibrahim Mazyed

A spirooxindole nanoformulation includes a proniosome loaded with a spirooxindole derivative. In an embodiment, the spirooxindole derivative comprises (Compound 4d)

Nanoformulation of spriooxindole and methods for treating hepatocellular carcinoma

The substituted spirooxindoles are MDM2-p53 inhibitors bearing a benzylidine (styryl) arm and have a complex fused ring system ideally suited for binding to the MDM2 protein, thereby interrupting its protein-protein interaction (PPI). Sixteen compounds, designated 4a-4p, were synthesized in a simple smooth method using an asymmetric 1,3-dipolar reaction as the key step. Testing showed that the compounds exhibit anti-cancer activity against various forms of cancer cells affecting humans.

Substituted spirooxindoles

Novel &#x3b1;-Glucosidase inhibitors include propanone substituted indole ring-containing heterocyclic compounds, which are represented by Formula I: Wherein  Ris thiophene, 2,4-di chloro phenyl, 2,6-di chloro phenyl, bromo phenyl, benzyl or nitrophenyl; and Ris an aryl group, or stereoisomers or pharmaceutically acceptable salts thereof.

&#x3b1;-glucosidase inhibitors

The diethylammonium salts of phenyl-substituted thiobarbituric acid as anti-diabetic agents include compounds having the formula: wherein X is: and wherein R1 is selected from the group consisting of a hydrogen, halogen, methyl, trifluoromethyl, methoxy, and nitro, and R2 is either halogen or hydrogen, the Rand Rsubstituents being independently bonded to an ortho-, meta-, or para-carbon of the phenyl substituent.

Diethylammonium salts of phenyl-substituted thiobarbituric acid as anti-diabetic agents

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Riyadh, Saudi Arabia

Assem Barakat