Ranbaxy Laboratories, Inc.

Sun Pharmaceutical Industries Limited

Asok Nath

Mohan Prasad

Hiten Sharadchandra Mehta

Subhash Dhar

Maneck Khurana

Deepak Mohanlal Jain

Dhiren C Barman

Rajesh Kumar

Abhay Tatiya

Pranab Chatterjee

Sanjay Mahadeo Gade

Ira Saxena

Prabhat Giri

Sarbjot Singh Sokhi

The present invention provides a process for the preparation of pazopanib of Formula Ia or salts, and intermediates thereof.

Process for the preparation of pazopanib or salts thereof

An improved and efficient process for the preparation of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid (febuxostat) that is substantially free from amide by-product is provided.

Process for the preparation of febuxostat

The present invention provides a process for preparation of crystalline aprepitant having not more than 15% by weight of Form I content which comprises, a) dissolving aprepitant in a suitable solvent to obtain a solution, b) cooling the solution to 10-15&#xb0; C., c) optionally seeding the solution with aprepitant Form I crystals, d) adding an anti-solvent to the solution, and e) isolating crystalline aprepitant having not more than 15% by weight of Form I content.

Process for the preparation of crystalline aprepitant having form I content

The present invention relates to a highly pure (2R,3S)-4-benzyl-3-(4-fluorophenyl)morpholin-2-yl 3,5-bis(trifluoromethyl)benzoate of Formula II, and a process for its preparation. The present invention further provides a process for preparation of Aprepitant of Formula I or pharmaceutically acceptable salt thereof, using the highly pure compound of Formula II. The present invention also provides a process for preparation of Aprepitant of Formula I or pharmaceutically acceptable salt thereof which comprises of cyclising the compound of Formula VII at elevated temperature, in the absence of solvent.

Process for the preparation of aprepitant

The present invention relates to processes for the preparation of intermediates of valsartan.

Processes for the preparation of intermediates of valsartan

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Gurgaon, India

Asok Nath