Leland Stanford Junior University

E. R. Squibb Sons, Inc.

Medarex Inc.

Asna Masood

David J King

Alison Witte

David B Passmore

Heidi N Leblanc

Kristopher Toy

Mark Yamanaka

Richard Theolis

Chetana Rao-Naik

Kyra D Zens

Dawn M Tanamachi

Tim Sproul

Sarah R Reed

Brian K Kobilka

Peter Brams

Dan Rohrer

Sara R Dwiggins

David John King

The present disclosure provides isolated monoclonal antibodies that specifically bind to CD22 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CD22, as well as methods for treating various cancers and inflammatory and autoimmune disorders using an anti-CD22 antibody of this disclosure.

Human antibodies that bind CD22 and uses thereof

An antibody that specifically binds a three dimensional epitope on the IC3 loop of a GPCR is provided. The antibody may be employed in a method that comprises: contacting a GPCR with a monovalent version of the antibody binding conditions to form a complex; and crystallizing the complex.

Method for obtaining G protein-coupled receptor (GPCR) diffraction-quality crystals employing a monoclonal antibody that binds to the third intracellular loop (IL3)

Growing community of inventors

Saratoga, CA, United States of America

Asna Masood