Council of Scientific and Industrial Research

Asmita Ashutosh Prabhune

Satishchandra Balkrishna Ogale

Pradeep Kumar Singh

Mukund Keshav Gurjar

Ramesh Anna Joshi

Rohini Ramesh Joshi

Snehal Vijay More

Anuya Amol Nisal

Colin Ratledge

Sachin Bharat Agawane

Ruchira Arup Mukherji

Parul Dubey

Kasturi Joshi-Navare

Philem Pushparani Devi

The present invention discloses a biodegradable and biocompatible pharmaceutical composition comprising silk Sericin, sophorolipid, a gelling or thickening agent and one or more pharmaceutically acceptable carriers or excipients for faster wound healing and limit scarring.

Pharmaceutical wound healing composition

The present invention provides a biocompatible hydrogel composition comprising glycolipids and silk fibroin (SF) wherein glycolipid is preferably sophorolipids (SL). The said composition is useful in preparation of 3D scaffold for use in tissue engineering, and in the biomedical field. The present invention also provides a process for preparing such a composition and a process for acceleration of gelation time of silk fibroin (SF) in the presence of sophorolipid.

Sophorolipid mediated accelerated gelation of silk fibroin

The present invention relates to a complex comprising acidic sophorolipid and curcumin ((SL(A)+Cur), wherein, curcumin is solubilized and nano-encapsulated in acidic sophorolipid to improve the water solubility, stability and bioavailability of curcumin in order to enhance its therapeutic activity. Further, the invention provides pharmaceutical compositions comprising the present complex and methods to treat cancer in a subject using the said composition.

Curcumin-sophorolipid complex

UV-Laser-synthesized, fluorescent, spherical and magnetic nanoparticles are loaded Sophorolipid mesostructures useful for bio-imaging and therapeutic applications.

Fluorescent, spherical sophorolipid mesostructures for imaging and therapeutic applications

The invention discloses synergistic pharmaceutical composition comprising an antibiotic and sophorolipid, to effectively combat the problem of antibiotic resistance by increasing the permeability of the antibiotic drugs across the outer membrane of bacteria. The sophorolipid being amphiphilic in nature can span through the structurally alike cell membrane and facilitate the entry of antibiotic drug molecules.

Pharmaceutical composition comprising sophorolipid in combination with an antibiotic

The present invention provides a process for preparation of optically active azabicyclo heptanone derivates using lactamases that will react with racemic lactam of formula (I) to give a single enanotiomer of lactam (III) and the corresponding ring opened compound of formula (IV) in an enantiomerically pure form.

Process for the preparation of optically active azabicyclo heptanone derivatives

The present invention relates to a novel process for the preparation of mixture of 19 hydroxyeicosatetraenoic acid and 20 hydroxyeicosatetraenoic acid (19 HETE and 20 HETE) by biotransformation of Arachidonic acid or Poly Unsaturated Fatty Acids (PUFA) with yeast as the biotransforming agent.

Growing community of inventors

Maharashtra, India

Asmita Ashutosh Prabhune