Nutech Ventures

University of Illinois

University of Nebraska

Asit K Pattnaik

Fernando Osorio

Hiep Lai Xuan Vu

William W Laegreid

Fangrui Ma

Nicholas Palermo

Shi-hua Xiang

Israrul H Ansari

Aryamav ' Pattnaik

Fernando A Osorio

This document relates to methods and materials for treating a mammal having a Zika virus (ZIKV) infection. For example, a composition including one or more non-nucleoside RNA polymerase inhibitors can be administered to a mammal having, or at risk of developing, a ZIKV infection to treat the mammal

Methods of treating or preventing Zika virus infection

A non-naturally occurring porcine reproductive and respiratory syndrome virus (PRRSV) is provided herein, and methods of making and using the non-naturally occurring PRRSV also are provided.

Non-naturally occurring porcine reproductive and respiratory syndrome virus (PRRSV) and methods of using

Pigs challenged with hypoglycosylated variants of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) major surface protein GP5 exhibited increased production of PRRSV-neutralizing antibodies relative to the levels of neutralizing antibodies produced by pigs immunized with wild type (wt) or glycosylated GP5. This invention provides for methods of obtaining improved immune responses in pigs to PRRSV, compositions useful for obtaining the improved immune responses as well as isolated polynucleotides that encode hypoglycosylated variants of PRRSV major surface protein GP5.

Methods and compositions for vaccination of animals with PRRSV antigens with improved immunogenicity

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Lincoln, NE, United States of America

Asit K Pattnaik