Council of Scientific and Industrial Research

Other

International Centre for Genetic Engineering and Biotechnology (icgeb)

International Centre for Genetic Engineering and Biotechnology

Asish Kumar Bhattacharya

Sushil Kumar

Ajit Kumar Shasany

Mahendra Pandurang Darokar

Ram Prakash Sharma

Dharam Chand Jain

Arvind Singh Negi

Hemender Rami Chand

Eswar Kumar Aratikatla

Suman Preet Singh Khanuja

Sunil Kumar Chattopadhyay

Dharmendra Saikia

Rajendra Singh Bhakuni

Atul Prakash Kahol

Suchi Srivastava

Sachin Srivastava

Sudeep Tandon

Ankur Garg

Suman Preet Khanuja

Tharun Kumar Kotammagari

Ashan Manhas

Togarrati Padmapriya

Pawan Malhotra

Manas Kumar Santra

Sunia Kumar Chattopadhyay

Kachin Srivastava

Tiruppadiripuliyur Ranganathan Kumar

Asif Mohmmed

Kumkum Srivastava

Mohammed Shafique Siddique

The present invention provides a new artemisinin-dipeptidyl vinyl based compound of Formula (I) or a pharmaceutically acceptable salt thereof and a process for the preparation thereof. The present invention further also provides a pharmaceutical composition comprising compounds of Formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent or excipient to treat malaria. 

Antimalarial compounds, process for preparation and their use for drug resistant malaria

The present invention relates to artemisinic acid glycoconjugate compounds. More particularly, the present invention relates to a glycoconjugate compound of formula (I) and a process for the preparation of artemisinic acid glycoconjugate compound of formula (I) by using 1,3-dipolar cycloaddition chemistry starting from artemisinic acid. 

Artemisinic acid glycoconjugate compounds, process for preparation and use thereof

The present invention discloses compounds of Formula I, wherein each of R, R, R, R, R, R, Rand Rare independently selected from H, OBn, OH, CHOBn, CHOH, CH; Ris selected from alkyl, substituted alkyl, hydroxyl alkyl, alkenyl, benzyl; process for preparation of N-alkylated glycolactam compounds of Formula I and their use for the synthesis of piperidine alkaloids and their analogues.

Glycolactam compounds, process for preparation and uses thereof

The present invention discloses anti-malarial compound of formula (I) Formula (I) wherein, X is selected from O or NH; R, R, R, Rand Ris selected from H or OMe or CH, &#x2014;CH&#x2014;O&#x2014;CH&#x2014; or &#x2014;CH&#x2550;CH&#x2014;CH&#x2550;CH&#x2014;; Y is selected from O or NH and R, Ris selected from the following compounds: or pharmaceutically acceptable salts thereof, process for preparation and a pharmaceutical composition containing the same. 

Aromatic derivatives as anti-malarial

The present invention discloses a process for synthesis of piperidine alkaloids selected from fagomine, 4-epi-fagomine and nojirimycin from tri-O-benzyl-D-glucal or tri-O-benzyl-D-galactal.

Process for synthesis of piperidine alkaloids

This invention provides a plant growth regulatory activity of a new biologically active synthetic molecule methanone-(3',4&#x2032;,5&#x2032;-trimethoxy) phenyl, 1-naphthyl, 2-O-4&#x2033;-ethyl but-2&#x2033;-enoate. More particularly, the invention relates to the potent plant growth promoting activity of a gallic acid derivative having a structure represented by Formula 1 and a molecular formulae CHO. This invention also provides a novel process for preparation of said molecule from a naturally occurring compound and testing it for growth regulating activity using Bacopa test system developed at CIMAP (Khanuja et al., 2001) 

Gallic acid derivative and process of preparing the same

Demethylation of 3', 4&#x2032;-dimethoxy or 3&#x2032;, 4&#x2032;, 5&#x2032;-trimethoxy benzoic ester of a phenol is carried out in the presence of an excess of aluminum halide in an organic solvent to get 4&#x2032;-Hydroxy, 3&#x2032;-methoxy or 4&#x2032; hydroxy, 3&#x2032;, 5&#x2032;-dimethoxy benzoic acid ester of a phenol. The reaction is also applicable to 3&#x2032;, 4&#x2032;, 5&#x2032;-trimethoxy diaryl ketone and some natural products like reserpine.

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The present invention relates to use .alpha.-arteether as a antibacterial agent, preferably for gyr mutant bacteria which are resistant to quinolone drugs and can be used as therapeutic agents for treating drug resistant bacterial infections, and also as a antifungal agent.

Method for the use of alpha arteether as an anti-bacterial and

This invention relates to a novel process for the dual production of essential oil and artemisinin from the plant Artemisia annua, said process comprising extracting the plant with hexane, partitioning the hexane extract between hexane and acetonitrile, hydrodistillation of hexane residue and Marc to yield essential oil, further fractionation of acetonitrile solvent between hexane-benzene mixture to remove artemisinic acid, chromatographing of the acetonitrile phase to produce substantially pure artemisinin, the artemisinic acid is reduced to obtain dihydro artemisinic acid which is then oxidised in a single step to form artemisinin.

Process for the simultaneous production of artemisnin and essential oil

Growing community of inventors

Pune, India

Asish Kumar Bhattacharya