Nir Diagnostics Inc.

Cme Telemetrix Inc.

Covidien LP

Niresults Inc.

Ashwani Kaushal

Duncan MacIntyre

James Samsoondar

Romuald Pawluczyk

Theodore E Cadell

Bronislaw Bednarz

Paul Drennan

John Kuta

The present invention provides a method of measuring the concentration of a compound and a value of oxygen saturation in the blood of a part of a subject. Also provided is a device for carrying out the disclosed method. The method relates to measuring the concentration of a compound and a value of oxygen saturation in the blood part of a subject, and correlating the measured concentration of the compound and/or the value of oxygen saturation in the blood to a specific clinical condition. The device comprises a polychromatic light source, a receptor, a detector, and a processing system comprising a calibration algorithm.

Method and apparatus for determining blood analytes

Diagnostic instrument

The present invention provides an apparatus and a method for identifying the risk of a clinical condition in a human or animal by correlating Near Infrared (NIR) absorbance spectral data with one or several parameters including a concentration of one or more substances in the skin, a concentration of one or more substances in skin plus subdermal tissue, a score derived from one or more clinical tests like a stress test on a treadmill, coronary angiography, or intravascular coronary ultrasound. The method determines the concentration of a compound in the skin of a human or animal and comprises the steps of placing a part of the skin against a receptor, directing electromagnetic radiation (EMR) from the near-infrared spectrum onto the skin, measuring a quantity of EMR reflected by, or transmitted through, the skin with a detector; and performing a quantitative mathematical analysis of the quantity of EMR to determine the concentration of the compound, for example free and esterfied cholesterol. An example of a clinical condition is cardiovascular disease.

Near infrared risk assessment of diseases

Handheld diagnostic instrument

The present invention provides a photometric reference member comprising PTFE and glass. The member exhibits an absorbance change of less than 0.0001 absorbance units per degree C. over a range of temperatures, preferably from about 20&#xb0; C. to about 40&#xb0; C., and over wavelengths from about 600 nm to about 1650 nm, preferably about 600 nm to about 1050 nm. The invention also pertains to methods of using the photometric reference member to correct for temperature variations or drift in absorbance measurements.

Device for reference measurement and photometric correction in non-invasive glucose measurement using near infrared spectroscopy

The present invention provides a thermally stable reference member comprising, at least one radiation attenuating element and at least one radiation scattering element. The radiation attenuating element comprising at least one aperture for transmission of radiation therethrough. The attenuating and scattering elements placed in series so that radiation transmitted through the reference member passes through each of the attenuating and scattering elements. The attenuating and scattering elements of the reference member may further comprise a thermally stable mount to hold the elements in a selected position relative to each other, and in relation to an instrument, or the elements may be bonded together. The radiation attenuating element may be comprised of a material selected from the group consisting of I, tungsten, brass, and a material substantially non-transparent for incident radiation, and the radiation scattering element may be comprised of a radiation scattering material selected from the group consisting of opalescent glass, S, PTFE, Z, fused silica, quartz, sapphire, diamond, and a transparent material with essentially low thermal expansion.

Electromagnetic radiation attenuating and scattering member with improved thermal stability

The present invention provides an artificial member ( ) which mimics the absorbance spectrum of a body part and includes the spectral components of blood analytes. The artificial member comprises a light scattering and reflecting material, and has a chamber portion comprising one or more chambers ( ). The artificial member is configured to be reproducibly received in a measuring receptor which receptor is operatively connected to a non-invasive monitoring device.

Device for verifying the accuracy of a spectral analyzer

An artificial member that mimics the absorbance spectrum of an animal body part and includes the spectral components of blood analytes is disclosed. The artificial member is made of a light scattering and reflecting material and is configured to be reproducibly received in a measuring receptor that is operatively connected to a non-invasive monitoring device.

Growing community of inventors

Mississauga, Canada

Ashwani Kaushal