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Merck Sharp + Dohme B.v.

Ashvinkumar Dhirubhai Mistry

Simon James Anthony Grove

Ronald Palin

Grant Wishart

Peter Christopher Ray

John Kinnaird Ferguson MacLean

Keneth Davies

Takao Kiyoi

Mark Reid

John Kinnaird Maclean

The present invention relates to a tricyclic heterocyclic derivative according to Formula (I), wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to pharmaceutical compositions comprising said tricyclic heterocyclic derivatives and to their use in therapy, for instance in the treatment or prevention of serotonin mediated disorders, such as obesity. 

Tricyclic heterocyclic derivatives

The invention relates to (pyrrolidin-2-yl)phenyl derivatives having the general Formula I wherein Ris (C)alkyl, halo(C)alkyl, (C)alkyloxy, or halo(C)alkyloxy; Ris H, (C)alkyl, halo(C)alkyl, (C)alkyloxy, halo(C)alkyloxy or halogen; Ris H, (C)alkyl or halo(C)alkyl; Ris H, (C)alkyl or halo(C)alkyl; Ris H, (C)alkyl or halo-(C)-alkyl; or Rand R, when bonded to the same carbon atom, can together with the carbon atom form a spiro(C)cycloalkyl group, optionally substituted with halogen; Ris H, (C)alkyl, halo(C)alkyl, (C)alkyloxy, halo(C)alkyloxy or halogen; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of these (pyrrolidin-2-yl)phenyl derivatives for the treatment of pain, such as neuropathic pain or inflammatory pain.

(Pyrrolidin-2-yl)phenyl derivatives

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Newhouse, United Kingdom

Ashvinkumar Dhirubhai Mistry