University of Michigan

Asociacion Instituto Nacional De Biodiversidad

Ashootosh Tripathi

David H Sherman

Amy E Fraley

Chuanwu Xi

Michael Marie Kaufman-Schofield

Jianfeng Wu

Giselle Tamayo

Pam Schultz

Pamela J Schultz

Fengan Yu

Sung Ryeol Park

The disclosure provides biocatalysts that halogenate complex chemical compounds in specific and predictable ways. Also disclosed are halogenated complex organic compounds. The disclosure further provides methods for the halogenation of complex chemical compounds and methods of inhibiting the contraction of smooth muscle in mammals.

Halogenation of complex organic compounds

Provided herein are biofilm inhibitors obtained from marine microbial derived natural product extracts from, resulting in biofilm inhibitors, cahuitamycins. Also provided are mutant, methods of inhibiting biofilm formation, methods of producing, or increasing the production of, cahuitamycins, methods for synthesizing cahuitamycins, and methods of purifying cahuitamycins.

Cahuitamycins and methods of making and using the same

Provided herein are compositions of compounds of formula (I), methods of inhibiting a bacterial infection by contacting a cell with a composition comprising a compound of formula (I), and methods of isolating compounds of formula (I) from an extract of

Baulamycins, compositions and methods of use thereof

Growing community of inventors

Ypsilanti, MI, United States of America

Ashootosh Tripathi