Abbott Laboratories Corporation

Bracco Imaging S.p.a.

Ashok V Bhatia

Xiu Chun Wang

Steven A Chamberlin

John J Hufnagel

Keith A Drengler

Richard A Lorenzini

David A Riley

Deborah A Davis

Luping Liu

Gregg E Robinson

Madhup K Dhaon

Timothy B Towne

Azad Hossain

Grant L Esser

Steve A Chamberlin

Greg E Robinson

The present invention discloses a process for the preparation of pure non-ionic contrast agents. The invention also includes a method for purifying the non-ionic contrast agents.

Process for the preparation of iopamidol

A compound and salts and enantiomers thereof, having the formula:wherein R7 is an acyl group.

Process for the preparation of Midazolam

The process of the present invention relates to a process for producing 1 3-cis retinoic acid. The process of the present invention involves reacting a Wittig salt in a solvent with a butenolide in the presence of a weak base and a Lewis acid.

Process for producing 13-cis retinoic acid

The present invention relates to a process for the selective alkylation of intermediates of betaxolol.

Process for the selective alkylation of betaxolol intermediates

A method for the preparation of D-chiro-inositol from kasugamycin, comprising the steps of: (a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate intermediate; (b) purifying the crude intermediate to form purified hexa-acetate intermediate; (c) deacetylating the purified intermediate to form D-chiro-inositol; and (d) isolating the D-chiro-inositol. The method permits efficient, large-scale preparation of D-chiro-inositol without the need for extensive chromatographic purification of the final D-chiro-inositol product.

Processes for the preparation of D-chiro-inositol

Polymers can be prepared in solution by continuously distilling solvent from a solution of diacid prepolymers.

Process for the preparation of polyanhydrides

Provided is a novel process for the preparation of iohexol having reduced number of isolated intermediates and significantly reduces or eliminates the use of ion-exchange resins required to desalinate the final product.

Process for the preparation of iohexol

Selective alkylation of an alcohol substituted phenol compound

Provided is a novel process for the preparation of iohexol having improved yields and purity, reduced number of isolated intermediates, and significantly reduced volume of ion-exchange resins required to desalinate the final product.

A process of producing atracurium besylate that substantially reduces the level of impurities in the final product and avoids the repeated use of ether is provided. In accordance with such a process, N, N'-4,10-dioxa-3,11-dioxotridecylene-1,13-bis-tetrahydropapaverine (Compound 1), methyl benzenesulfonate and a catalytic amount of an insoluble base in a solvent are combined to form a reaction mixture that is maintained for a period of time sufficient for atracurium besylate formation. The reaction mixture is then filtered to remove the insoluble base and the atracuriurn besylate is precipitated.

Process for the preparation and isolation of atracurium besylate

A method for the preparation of D-chiro-inositol from kasugamycin, comprising the steps of:

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Libertyville, IL, United States of America

Ashok V Bhatia