Ranbaxy Laboratories, Inc.

Ashok Rattan

Biswajit Das

Sonali Rudra

Anita Mehta

Sudershan Kumar Arora

Abhijit Ray

Ashwani Kumar Verma

Mohammad Salman

Jitendra Anant Sattigeri

Rita Katoch

Jasbir Singh Arora

Sangita Sangita

Arora K Sudershan

Mohammed Salman

Provided herein are novel substituted phenyl oxazolidinones and to processes for the synthesis thereof. Also provided are pharmaceutical compositions comprising one or more compounds described herein The compounds described can be useful antimicrobial agents, which can be effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiple-resistant staphylococci, streptococci and enterococci, as well as, anaerobic organisms, such asspp. andspp. species, and acid fast organisms, such asandspp.

Oxazolidinone derivatives as antimicrobials

The present invention relates to certain substituted phenyl piperazinyl oxazolidinones, for example, to those having the structure of Formula Iwith the variables as defined within, and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such asspp. andspp. species, and acid fast organisms such asandspp.

Oxazolidinone piperazinyl derivatives as potential antimicrobials

The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as and Mycobacterium spp.

The present invention relates to the derivatives of specially substituted azole compounds which have improved antifungal activity as compared with presently available agents in this class and the processes for the preparation thereof. This invention also relates to pharmaceutical preparations containing the compounds of the present invention and their use in treating and/or preventing the fungal infections in mammals, preferably humans.

Azole compounds as anti-fungal agents

The present invention relates to the derivatives of specially substituted azole compounds which have improved antifungal activity as compared to known compounds such as fluconazole and itraconazole and the processes for the preparation thereof. This invention also relates to pharmaceutical compositions containing the compounds of the present invention and their use in treating and/or preventing fungal infections in mammals, preferably humans.

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New Delhi, India

Ashok Rattan