Forest Laboratories, Inc.

Ashok Nigalaye

Norman G Gaylord

Joseph M Schor

A therapeutically active solid unit dosage form comprising a carrier base material combined with a therapeutically active medicament and shaped and compressed to a solid unit dosage form having a controlled and sustained release pattern upon administration, the carrier base material comprising a mixture of one or more nonionic cellulose ethers and an alkali metal carboxylate, wherein at least one of the cellulose ethers is hydroxypropylmethylcellulose having a number average molecular weight of at least 50,000.

Sustained release drug dosage forms containing

A carrier base material combined with a therapeutically active medicament and shaped and compressed to a solid unit dosage form having a regular and prolonged release pattern upon administration, the carrier base material being one or more hydroxypropylmethylcelluloses or a mixture of one or more hydroxypropylmethylcelluloses and up to 30% by weight of the mixture of methylcellulose, sodium carboxymethylcellulose and/or other cellulose ether, and wherein at least one of the hydroxypropylmethylcelluloses has a methoxy content of 16-24 weight-%, a hydroxypropoxyl content of 4-32 weight-% and a number average molecular weight of at least 50,000 and wherein the carrier base material constitutes less than about one third of the weight of the solid unit dosage form.

Sustained release therapeutic compositions based on high molecular

A carrier base material combined with a therapeutically active medicament and shaped and compressed to a solid unit dosage form having a regular and prolonged release pattern upon administration, the carrier base material being hydroxypropylmethylcellulose or a mixture of hydroxypropylmethylcellulose and up to 30% by weight of the mixture of ethylcellulose and/or up to 30% by weight of the mixture of sodium carboxymethylcellulose, and wherein the hydroxypropylmethylcellulose has a hydroxypropoxyl content of 9-12 weight % and a number average molecular weight of less than 50,000.

Growing community of inventors

East Rockaway, NY, United States of America

Ashok Nigalaye