Council of Scientific and Industrial Research

Ashok Kumar Tikoo

Ghulam Nabi Qazi

Rakesh Kamal Johri

Subhash Chander Sharma

Naresh Kumar Satti

Krishan Avtar Suri

Om Parkash Suri

Inshad Ali Khan

Kasturi Lal Bedi

Vijeshwar Verma

Bishan Datt Gupta

Manoj Kumar Tikoo

Subhash Chandra Taneja

Anamika Khajuria

Surrinder Koul

Ashwani Kumar

Bal Krishan Kapahi

Jawahir Lal Koul

Ravi Kant Khajuria

Pankaj Gupta

Zahid Mehmood Mirza

Surjit Singh

Monika Pandita

Anita Khosa

Sheikh Tasaduq Abdullah

Sheikh Tasaduq Absullah

The present invention relates to an aromatic substituted pentadienoic acid amides and there use in combination of specific amounts of aromatic amides i.e. 4-alkyl-5-(substituted phenyl)-2 (E),4(E)-pentadienoic acid amides, its geometrical isomers or their dihydro or tetrahydro derivatives and an anti-infective drug useful in potentiating the bioefficacy of antiinfective drug. The combination of the present invention is useful in the treatment of certain infections and disease at lower concentration of anti-infectives necessary to inhibit the growth of microbial strains and may also find applications in reducing the resistance in microorganisms.

Aromatic amides as potentiators of bioefficacy of anti-infective drugs

The present invention relates to an aromatic substituted pentadienoic acid amides and there use in combination of specific amounts of aromatic amides i.e. 4-alkyl-5-(substituted phenyl)-2(E),4(E)-pentadienoic acid amides, its geometrical isomers or their dihydro or tetrahydro derivatives and an anti-infective drug useful in potentiating the bioefficacy of antiinfective drug. The combination of the present invention is useful in the treatment of certain infections and disease at lower concentration of anti-infectives necessary to inhibit the growth of microbial strains and may also find applications in reducing the resistance in microorganisms.

The present invention relates to a bioenhancing/bioavailability-facilitating composition comprising:

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The present invention relates to the use of bioenhancers to decrease the resistance of microbial strains to anti-infective such an antibiotics and antifungals by potentiating the activities of anti-infective. This may be useful to reduce resistance in bacteria and yeast to aid in the treatment of certain infections and disease and to lower the concentration of antiinfectives necessary to inhibit the growth of microbial strains.

Use of herbal agents for potentiation of bioefficacy of anti infectives

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Jammu Tawi, India

Ashok Kumar Tikoo