Council of Scientific and Industrial Research

Ashok Kumar Khanna

Ramesh Chander

Nitya Anand

Ram Pratap

Arvind Kumar Srivastava

Anil Kumar Rastogi

Omkar Prasad Asthana

Deepak Raina

Ram Chandra Gupta

Narinder Kumar Kapoor

Satyavan Singh

Savita Srivastava

Swarn Nityanand

Ashim Ghatak

Sukh Dev

Sushil Kumar

Tajuddin

Santosh Kumar Agarwal

Mohammad Shafiq Siddiqui

The invention provides a method of using pregnadienones and pregnadienols represented by the structural formula (I) as shown herein belowWherein X&#x2550;OH or O or combination thereof and positioning of olefinic bonds are at 4(5); 5(6); 16(17); 17(20) or various combinations and said compounds containing at least one olefinic bond in or on their D-ring for the treatment of hyperlipidemic and hyperglycemic conditions in mammals, said method comprising administering an effective amount of the said compounds to the recipient mammals.

Method of treating hyperlipidemic and hyperglycemic conditions in mammals using pregnadienols and pregnadienones

A process for the isolation of a lipid fraction containing Z & E guggulsterones useful as cholesterol lowering drug, which comprises soaking/soxhlet extracting the powdered aerial part of the plant C. wightii with a non polar solvent, filtering/deanting the extract, soaking the material again in a polar solvent, filtering and concentrating the extracted material under reduced pressure as to obtain a thick viscous extract, and subjecting the thick viscous extract to gel filteration/silica gel chromatography to obtain Z & E ketosteroid containing lipid fraction exhibiting hypolipidemic activity.

Process for the isolation of Z and E gugulsterones from aerial branches

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Lucknow, India

Ashok Kumar Khanna