Wyeth

Ashok Bapat

Mark James Evans

Sotirios K Karathanasis

Marshall S Scicchitano

Ramesh A Bhat

Robert Mastroeni

Frederick J Bex

Emily Sheng-Ming Shen

Vargheese M Chennathukuzhi

Murty V Chengalvala

Panayiotis E Stevis

Yogendra P Kharode

Gregory S Kopf

The invention provides methods for treating or preventing bone degenerative disorders. The disorders treated or prevented include, for example, osteopenia, osteomalacia, osteoporosis, osteomyeloma, osteodystrophy, Paget's disease, osteogenesis imperfecta, and bone degenerative disorders associated with chronic renal disease, hyperparathyroidism, and long-term use of corticosteroids. The disclosed therapeutic methods include administering to a mammal an inhibitor of GDF-9 or BMP-15 in an amount effective to: (1) treat or prevent a bone degenerative disorder; (2) slow bone deterioration; (3) restore lost bone; (4) stimulate new bone formation; and/or (5) maintain bone mass and/or bone quality. The invention also provides methods for administering a GDF-9 agonist or a BMP-15 agonist to treat a bone disorder characterized by increased bone density or mass.

GDF-9/BMP-15 modulators for the treatment of bone disorders

The present invention relates to a novel lysyl oxidase genes, termed EER-7. The invention relates to the protein and nucleic acids encoding the protein. The invention further relates to an assay system to identify compounds that selectively modulate EER-7 protein activity by interaction with estrogen receptors.

Member of the lysyl oxidase gene family

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Blue Bell, PA, United States of America

Ashok Bapat