The Charles Stark Draper Laboratory, Inc.

Massachusetts Institute of Technology

The Charles Draper Laboratory, Inc.

Ashley Lynne Beckwith

Jeffrey T Borenstein

Nathan Francis Moore

Daniel Doty

Luis Fernando Velásquez-Gracía

Luis Velásquez-García

This disclosure describes techniques for fabricating a high-resolution, non-cytotoxic and transparent microfluidic device. A material can be selected based on having an optical property with a predetermined degree of transparency to provide viewability of a biological sample through the microfluidic device and a level of cytotoxicity within a predetermined threshold to provide viability of the biological sample within the microfluidic device. An additive manufacturing technique can be selected from a plurality of additive manufacturing techniques for fabricating the microfluidic device based on the selected material to provide a resolution of dimensions of one or more channels of the microfluidic device higher than a predetermined resolution threshold.

Systems and methods for fabricating microfluidic devices

This disclosure describes microfluidic tissue biopsy and immune response drug evaluation devices and systems. A microfluidic device can include an inlet channel having a first end configured to receive a fluid sample optionally containing a tissue sample. The microfluidic device can also include a tissue trapping region at the second end of the inlet channel downstream from the first end. The tissue trapping region can include one or more tissue traps configured to catch a tissue sample flowing through the inlet channel such that the fluid sample contacts the tissue trap. The microfluidic device can also include one or more channels providing an outlet.

Microfluidic tissue biopsy and immune response drug evaluation devices and systems

Growing community of inventors

Cambridge, MA, United States of America

Ashley Lynne Beckwith