Baker Hughes Corporation

William Marsh Rice University

The University of Texas System

Baylor College of Medicine

Ashley Leonard

James Mitchell Tour

Oleg Antonovych Mazyar

Joshua C Falkner

Dmitry Kosynkin

Jacob Berlin

S Ward Casscells

Jared L Hudson

Jeffrey N Myers

Luka Milas

Kathy A Mason

Brandi Katherine Price

Thomas Andrew Kent

Robia G Pautler

Valerie C Moore

Daniela Marcano

Rebecca Lucente-Schultz

Brittany Bitner

Jodie L Conyers, Jr

Taeko Inoue

Zvonimir L Milas

In some embodiments, the present invention provides methods of treating oxidative stress in a subject by administering a therapeutic composition to the subject. In some embodiments, the therapeutic composition comprises a carbon nanomaterial with anti-oxidant activity. In some embodiments, the anti-oxidant activity of the carbon nanomaterial corresponds to ORAC values between about 200 to about 15,000. In some embodiments, the administered carbon nanomaterials include at least one of single-walled nanotubes, double-walled nanotubes, triple-walled nanotubes, multi-walled nanotubes, ultra-short nanotubes, graphene, graphene nanoribbons, graphite, graphite oxide nanoribbons, carbon black, oxidized carbon black, hydrophilic carbon clusters, and combinations thereof. In some embodiments, the carbon nanomaterial is an ultra-short single-walled nanotube that is functionalized with a plurality of solubilizing groups. In some embodiments, the carbon nanomaterial is a polyethylene glycol functionalized hydrophilic carbon cluster (PEG-HCC). In some embodiments, the administered therapeutic compositions of the present invention may also include an active agent or targeting agent associated with the carbon nanomaterial. Additional embodiments of the present invention pertain to the aforementioned carbon nanomaterial compositions for treating oxidative stress.

Use of carbon nanomaterials with antioxidant properties to treat oxidative stress

In an embodiment is a seal including an elastomer; and boron nitride nanoparticles disposed in the elastomer, wherein the seal is thermally conductive and electrically insulating. In another embodiment, is a method of making a seal, the method includes compounding an elastomer with boron nitride nanoparticles to provide a composition; and molding the composition into a shape.

Thermally conductive nanocomposition and method of making the same

A nanocomposite fluid includes a fluid medium; and a nanoparticle composition comprising nanoparticles which are electrically insulating and thermally conductive. A method of making the nanocomposite fluid includes forming boron nitride nanoparticles; dispersing the boron nitride nanoparticles in a solvent; combining the boron nitride nanoparticles and a fluid medium; and removing the solvent.

Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.

Water-soluble carbon nanotube compositions for drug delivery and medicinal applications

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Houston, TX, United States of America

Ashley Leonard