The United States of America, As Represented by the Secretary, Department of Health and Human Services

Ashley A Jaeger

Thomas J Pohida

Michael M Gottesman

Nicole Y Morgan

Chandan Das

Randall H Pursley

Philip G McQueen

The present disclosure is directed to embodiments of microstructured membranes, methods of fabricating microstructured membranes, bioreactors housing microstructured membranes, and methods of using bioreactors and microstructured membranes. In some embodiments, the present disclosure allows culturing of cellular tissues in an environment which more accurately resembles a native environment. In some more specific embodiments, the present disclosure allows culturing of tumor cells on a membrane having a microfabricated pattern which mimics a native vasculature system.

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North Bethesda, MD, United States of America

Ashley A Jaeger