Southern Research Institute

Oregon Health & Science University

The University of Texas System

Washington University

The University of North Carolina at Chapel Hill

Vanderbilt University

The UAB Research Foundation (The University of Alabama at Birmingham)

Western Illinois University Research Foundation

Ashish Kumar Pathak

Corinne E Augelli-Szafran

Nicole Haese

Syed Kaleem Ahmed

Joseph A Maddry

Rebecca Boohaker

Daniel Streblow

Omar Moukha-Chafiq

Jessica Lee Smith

Alec Jay Hirsch

William Madison Parks

Atefeh Garzan

Saibal Chakraborty

Mark J Suto

Subramaniam Ananthan

Ralph Baric

Michael S Diamond

Andrew Wayne Cain

Larry D Bratton

Timothy Patrick Sheahan

John Phillip Tillotson

Mark R Denison

Robert A Galemmo, Jr

Amy Catherine Sims

Shilpa Dutta

Daniel Steblow

Theresa Ha Nguyen

Baoling Ying

Shuklendu D Karyakarte

Pei Yong Shi

Richard D May

Vibha Pathak

Anisia J Silva-Benitez

Jorge A Benitez

Jacob Valiyaveettil

Andrew B West

Robert A Galemmo

The present disclosure is concerned with 2-pyrimidone compounds that are capable of inhibiting a viral infection and methods of treating alphavirus viral infections such as, for example, chikungunya, Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), and Venezuelan equine encephalitis using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

2-pyrimidone analogs as potent antiviral agents against Alphaviruses

The present disclosure is concerned with substituted phenyl ethynyl pyridine carboxamide compounds, pharmaceutical compositions comprising the compounds, and methods of treating viral infections due to a Coronavirus such as, for example, Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus disease 2019 (SARS-CoV-2), using the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Substituted phenyl ethynyl pyridine carboxamides as potent inhibitors of SARS virus

The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

6-aza-nucleoside prodrugs as antiviral agents for treating virus infections

The present disclosure is concerned with xanthine analogs, methods of making xanthine analogs, and methods of treating West Nile virus using these analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Xanthine analogs as potent anti-West Nile viral agents

2-pyrimidone analogs as potent antiviral agents against alphaviruses

Disclosed herein is an aerogel made from a polyhydroxy benzene compound crosslinked with formaldehyde. The aerogel is dry and has a first volume and wherein the aerogel can be exposed to a liquid and be re-dried in a gas while retaining at least 70% of the first volume.

Porous material and methods related thereto

The present disclosure is concerned with benzoannulene compounds that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, chikungunya, Venezuelan equine encephalitis, dengue, influenza, and zika, using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Benzoannulene derivatives as antiviral agents

The present disclosure is concerned with benzo annulene compounds that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, chikungunya, Venezuelan equine encephalitis, dengue, influenza, and zika, using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Benzo annulenes as antiviral agents

Provided are novel LRRK2 kinase inhibitors and methods of treating disease states using these inhibitors. Examples of LRRK2 kinase inhibitors are compounds of the formula: or derivatives thereof. An example is 1-(piperidin-1-yl)-2-((3-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)butan-1-one. Particular uses include treating neurodegenerative diseases, cancer, autoimmune diseases and leprosy.

Triazolopyridazine compounds, use as inhibitors of the kinase LRRK2, and methods for preparation thereof

Certain compounds are provided that can selectively inhibit motile bacteria such asmotility. These compounds can indirectly diminish production of cholera toxin and other major virulence required by the cholera bacterium to cause disease.

Small molecule inhibitors of bacterial motility and a high throughput screening assay for their identification

Methods and immunogenic compositions for generating an immune response against Marburg virus are provided. The immunogenic composition includes antigens obtained from a Marburg viral strain in combination with an oleanolic acid triterpene adjuvant.

Adjuvant

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Ashish Kumar Pathak