Illumina Corporation

Illumina Singapore Pte. Ltd.

Ashish Kumar

David Elliott Kaplan

Anthony John De Ruyter

Richard Alan Kelley

Lea Kobeli

Edward Wilson Licitra

James Michael Osmus

Peter Clarke Newman

Erik Lewis Williamson

Max Warren Pollock

Robert Nicholas Dean

Richard L Lemoine

Raymond Lawrence Oyung

Venkatesh Mysore Nagaraja Rao

Kevin Michael Festini

Richard Lemoine

Flow cell cartridge

Gasket assemblies and related system and methods. An apparatus includes a system, a flow cell, and a plurality of gasket assemblies. The system includes a flow cell interface and the flow cell has one or more channels. Each channel has a first channel opening and a second channel opening. The first channel openings are positioned at a first end of the flow cell and the second channel openings are positioned at a second end of the flow cell. A gasket assembly coupled at each second channel opening. Each gasket assembly includes an adhesive stack and a gasket. The adhesive stack includes a first side bonded to the gasket and a second side bonded to the flow cell. The flow cell interface is engagable with the corresponding gaskets to establish a fluidic coupling between system and the flow cell.

Flow cell assemblies and related systems

A cartridge for use with chemical or biological analysis systems, as well as methods of using the same, is provided. The cartridge may include a floating microfluidic plate that is held in the cartridge using one or more floating support brackets that incorporate gaskets that may seal against fluidic ports on the microfluidic plate. The floating support brackets may include indexing features that may align the microfluidic plate with the seals.

Flowcell cartridge with floating bracket

Flowcell cartridge with floating seal bracket

Temperature-controllable reagent cartridges and systems for controlling the temperature in such reagent cartridges are provided. An example such system may include a reagent cartridge having reagent reservoirs located at least in part within an interior plenum volume of a cartridge housing. In such an example system, each reagent reservoir may be defined, in part, by a sidewall, and a first reagent reservoir may be spaced apart from a second reagent reservoir to form a fluid flow passage between corresponding sidewalls thereof. A fluid inlet through the cartridge housing may be provided that fluidically connects the interior plenum volume with a fluid supply port of a temperature control system of an analysis instrument when the reagent cartridge is received by the analysis instrument; a fluid outlet through the cartridge housing that fluidically connects the interior plenum volume with a fluid return port of the temperature control system may also be provided.

Temperature-controllable reagent cartridge and temperature control system for the same

A cartridge for use with chemical or biological analysis systems is provided. The cartridge may include a floating microfluidic plate that is held in the cartridge using one or more floating support brackets that incorporate gaskets that may seal against fluidic ports on the microfluidic plate. The floating support brackets may include indexing features that may align the microfluidic plate with the seals.

Flowcell cartridge

An optical cleaning cartridge for automated cleaning of optical components of analysis instruments is disclosed.

Optical cleaning cartridge

Full flowcell cartridge

Growing community of inventors

San Diego, CA, United States of America

Ashish Kumar