Council of Scientific and Industrial Research

Ashish

Amin Sagar

Renu Garg

Nagesh Peddada

Ashwani Kumar

Yogendra Singh Rathore

Kanika Dhiman

Kunzes Dolma

Shiv Pratap Singh Yadav

Maulik Dinesh Badmalia

An in vitro method for detecting presence of cancer includes obtaining a single hair sample. An x-ray beam is emitted from a source towards the hair sample. A small angle X-ray scattering (SAXS) intensity profile is generated after the x-ray beam hits the hair sample. The SAXS profile is received on a detector to obtain SAXS data, which is desmeared and Kratky Analysis is performed. A relative estimation of peak area under 1.38 nmto 0.89 nmfrom keratin and lipid content in the hair sample is performed to obtain R and is corrected by dividing by D, thickness of the hair. R' is computed using formula: 10&#xd7;R/(D&#x2212;R). The value of R&#x2032; is compared with clinically validated samples. If R&#x2032; value is below 0.7, it indicates the presence of cancer and if it is above 0.8, it indicates absence of cancer.

Non-invasive and remote method to screen cancer

The present invention relates to an in-vitro method of detecting Mtb infection by using SAXS profile of hair sample. The invention is an approach to overcome the problem of non-invasively and cost-effectively yet reliably diagnosing presence of active tuberculosis in the patient. There would be no risk to the sample handlers getting infected from the sample, cross-contamination of samples, low cost and quick turn-around time of diagnosis.

In vitro method for detecting active mycobacterium tuberculosis using hair small angle x-ray scattering profile

The present invention relates to a process which uses blue light to form bio-organic coated silver and gold nanoparticles for various applications. The present invention particularly relates to increasing the rates of reaction and widening the scope of tethering a range of biomolecules on the metal nanoparticles. The examples demonstrate that the biomolecules immobilized on the nanoparticles still retain many aspects of their structural elements which allow them to bind to their native binding partners and/or retain structural epitopes which allow them to be identified by antibodies specific to them, thus opening up scope of using such coated nanoparticles for functionalized and specific applications.

Process for the preparation of bio-organic coated gold and silver nanoparticles using blue light

The present invention relates to novel DNA aptamers capable of binding gelsolin tightly and specifically. The invention further relates to the use of these aptamers to estimate the gelsolin levels in a given sample and purify bulk quantities of tagless gelsolin and its variants. The present invention thus eliminates the use of different animals/their tissues to produce gelsolin binding proteins, which are much more expensive and socially unacceptable methods as opposed to the synthesis of a DNA molecule by in vitro PCR. Using this strategy, bulk production of the gelsolin binding matrix can be carried out at much lower cost. Also, the aptamers can be used to block binding of gelsolin to its binding partners for diagnostic and/or therapeutic applications.

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Chandigarh, India

Ashish