Pfizer Corporation

Asato Morita

Hiroki Koike

Fumitaka Ito

A compound of the formula:or a pharmaceutically acceptable salt, ester or ether thereof, wherein Rthrough Rare independently hydrogen or the like; Xand Xare independently CHor the like; Ris hydrogen or the like; or Rand Rtaken together with three ring atoms of the quinoline ring separating said substituents form a heterocyclic ring; Rand Rare hydrogen or the like or these groups taken together form oxo; and the dotted line represents a single or double bond. These compounds are ligands for ORL-1 receptor and especially are antagonists for said receptor.

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Aichi-ken, Japan

Asato Morita