Takeda Pharmaceutical Company Limited

Asato Kina

Takeshi Yamasaki

Tsuneo Yasuma

Shizuo Kasai

Tohru Yamashita

Hideki Hirose

Minoru Yoshida

Hideyuki Igawa

Yoichi Nishikawa

Makoto Kamata

Nobuyuki Takakura

Tsuyoshi Maekawa

Masaki Ogino

Masataka Murakami

Keiko Kakegawa

Ikuo Fujimori

Zenichi Ikeda

Jumpei Aida

Ryo Mizojiri

Kazuko Yonemori

Mrinalkanti Kundu

Takuya Fujimoto

Sachie Morimoto

Takashi Nakahata

Uttam Khamrai

Michiko Amano

A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: 

Tetrahydronaphthyridine somatostatin receptor 5 antagonists

Provided is a compound represented by the following formula (1) or a salt thereof, which has an SSTR5 antagonistic action: wherein each symbol has the same definition as in the specification. 

Spiro azetidine isoxazole derivatives and their use as SSTR antagonists

The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula wherein each symbol as defined in the specification, or a salt thereof.

Aromatic ring compound

Benzimidazole derivatives as MCH receptor antagonists

A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: wherein each symbol is as defined herein, or a salt thereof, a medicament comprising the compound or a salt thereof, and use of the compound or a salt thereof as an agent for the prophylaxis or treatment of diabetes mellitus are provided.

A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: wherein each symbol is as defined herein,or a salt thereof, a medicament comprising the compound or a salt thereof, and use of the compound or a salt thereof as an agent the prophylaxis or treatment of diabetes mellitus are provided.

Heterocyclic compound

The present invention provides a compound having an ACC inhibitory action, which is useful as an agent for the prophylaxis or treatment of obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia, cancer and the like, and has superior efficacy. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Bicyclic compound

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Kanagawa, Japan

Asato Kina