Takeda Pharmaceutical Company Limited

Asae Shintani

Yasuo Sugiyama

Masatoshi Hazama

The present invention provides a TGF-&#x3b2; superfamily production/secretion promoter comprising a compound represented by the formula wherein Ris a halogen atom, an optionally substituted heterocyclic group, an optionally substituted hydroxy group, an optionally substituted thiol group or an optionally substituted amino group; A is an optionally substituted acyl group, an optionally substituted heterocyclic group, an optionally substituted hydroxy group or an optionally esterified or amidated carboxyl group; B is an optionally substituted aromatic group; X is an oxygen atom, a sulfur atom or an optionally substituted nitrogen atom; and Y is a divalent hydrocarbon group or heterocyclic group, or a salt thereof or a prodrug thereof, which is useful as an agent for the prophylaxis or treatment of dysautonomia, bladder dysfunction, hearing impairment, bone disease and the like.

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Suita, Japan

Asae Shintani