Rca Inc.

General Electric Company

Sarnoff Corporation

Other

US Government As Represented by the Secretary of the Army

Vidamed, Inc.

Amt Pte. Ltd.

Medtronic Ardian Luxembourg S.a.r.l.

Medtronic Ireland Manufacturing Unlimited Company

Drexel University

Ep Technologies, Inc.

Arye Rosen

Paul Walinsky

Paul J Stabile

Stewart Mark Perlow

Mark Gelfand

Stuart D Edwards

Denise Marie Zarins

Roman Turovskiy

Karun D Naga

Aly Eid Fathy

Hugh R Sharkey

Ronald G Lax

Ingemar H Lundquist

Peter R Herczfeld

Peter John Zanzucchi

Satyam Choudary Cherukuri

Herbert J Wolkstein

Bernard Dov Geller

Pamela Kay York

Zygmond Turski

David Norman Ludington

Gordon C Taylor

Edward Mykietyn

Arnold J Greenspon

Paul Heaney

Har'el Rosen

Jerome Barnard Klatskin

Pang-Ting Ho

Jerome B Klatskin

Roger Alan Stern

Jerome D Jackson

Daniel D Mawhinney

Fred Sterzer

Pradyumna Kumar Swain

Joseph H Abeles

Arthur C Paolella

Chung P Wu

William H Meise

Philip C Basile

Afshin S Daryoush

William P Santamore

Louis Sebastian Napoli

Sridhar Kanamaluru

Jitendra Goel

Robert W Paglione

Raymond Louis Camisa

Walter M Janton

Chi Hsiang Lee

Giora Griffel

Danielle Rosen

Robert N Hurwitz

Carmen E Rodriguez

Joseph R Delmaster, Jr

Richard A Hsi

Daniella Rosen

Barry H Stevens

Moniem Esherbiny

Kevin W Choi

Henry Charles Johnson

Anna M Gombar

John P Kurmer

Douglas A Wille

Microwave catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a microwave transmission element to a renal artery via an intravascular path. Renal neuromodulation may be achieved via dielectric heating in the presence of microwave irradiation that modulates neural fibers that contribute to renal function or alters vascular structures that feed or perfuse the neural fibers.

Catheter apparatuses, systems, and methods for neuromodulation

Microwave catheter apparatuses, systems, and methods for renal neuromodulation

An apparatus for optically generating signals comprises a mode-locked optical radiation source that generates mode-locked optical radiation with emitted modes separated by approximately 10 to approximately 300 GHz. Coupled to the optical radiation source is an optical demultiplexer with a demultiplexer input, a first demultiplexer output, and a second demultiplexer output, the demultiplexer input being coupled to said mode-locked radiation source. Additionally, the apparatus comprises an optical modulator having a modulator input and a modulator output, the modulator input being coupled to the first demultiplexer output, and an optical multiplexer having a first multiplexer input, a second multiplexer input, and a multiplexer output, the first multiplexer-input being coupled to the modulator output, the second multiplexer input being coupled to said second demultiplexer output.

Optical signal generator

A photodynamic therapy method administers, to a patient to be treated, a photosensitive medication which fluoresces when illuminated. The fluorescent light is an indication of the instantaneous phototherapy dose. A catheter according to the invention includes a probe or sensor arrangement for generating a signal representing the instantaneous amplitude of the fluorescence or the incident illumination. The signal is integrated to produce a signal representing the total dose of phototherapy. The photodynamic therapy is terminated when the integrated signal indicates a particular value. The catheter in one embodiment includes an array of semiconductor light sources near its distal end, energized from the proximal end. In another embodiment, the light source is external to the patient, and the light is conducted to the distal end of the catheter by one or more optical fibers. The light sensor may be an optical fiber extending from the proximal to the distal end of the catheter, with a probe end which is directive or omnidirectional. In this case, the dose signal is detected by a photodiode exterior to the catheter and the detected signal is integrated to generate a signal indicative of cumulative dose. In another embodiment, the photodiode is located near the distal end of the catheter.

Method and apparatus for catheter phototherapy with dose sensing

A surface PIN (SPIN) device and a method of fabricating such a SPIN device. The SPIN device, when activated, confines carrier injection to a small volume near the surface of the device such that the device is sufficiently conductive to simulate a planar conductor. The SPIN device comprises a P&plus; region and an N&plus; region formed in an intrinsic (I) layer. The P&plus; and N&plus; regions are separated by a lateral length of intrinsic material of length L. The length L is approximately the carrier diffusion length. When DC bias is applied across the N&plus; and P&plus; regions carriers are injected into the intrinsic region at a density exceeding 10 carriers per cubic cm. The intrinsic region is sufficiently thin to confine the carriers near the surface of the intrinsic region. As such, in the &ldquo;on&rdquo; state, the SPIN device simulates a conductive material. In the &ldquo;off&rdquo; state, the SPIN device is no longer conductive. Consequently, a planar array of SPIN devices can be fabricated and selectively activated to form a dynamic, reconfigurable antenna.

Surface PIN device

A reconfigurable antenna capable of dynamic reconfigurability of several antenna parameters. Specifically, the present invention is an antenna comprising a plurality of surface PIN devices arranged in a gridlike array. Each of the SPIN devices can be individually activated or deactivated. When a SPIN device is activated, the surface of the device is injected with carriers such that a plasma is produced within the intrinsic region of the device. The plasma can be sufficiently conductive to produce conductor or metal like characteristics at the surface of the device. Various ones of the SPIN devices can be activated to electronically paint a conductive pattern upon the substrate supporting the PIN devices. Through selective activation of the SPIN devices various surface antenna patterns can be produced upon the substrate including dipoles, cross dipoles, loop antennas, Yagi-Uda type antennas, log periodic antennas, and the like. Additionally, the SPIN device grid may be selectively activated to produce holographic antennas. In a holographic antenna the SPIN devices are activated to produce a simulated metallization pattern that is excited by a surface RF wave transmitted onto the substrate from a surface mounted dipole antenna. The surface wave excites a particular antenna pattern depending upon the shape of the activated SPIN devices. Changing the pattern of the holographic antenna elements causes a beam steering and/or frequency adjustments of the antenna.

Reconfigurable antenna

A tuning circuit, as for a television receiver or video recorder, employs switchable tuning circuits including micro-electronic electro-mechanical switches for selecting the ones of an array of capacitors and/or inductors as is useful in tunable circuits. The array of capacitors and/or inductors and micro-electro-mechanical switches of the switched tuning matrix is formed on an integrated circuit or an electronic circuit substrate along with amplifiers and other electronic elements of the tuning circuit for which the switched tuning matrix is employed. The switchable capacitance and inductance matrices are well suited for use in the resonators employed in the pre-selector filters, post-selector filters and oscillators of electronic tuners, such as those employed in television receivers and video recorders. The capacitors and micro-electro-mechanical switches may be connected to select a particular capacitor of the array of capacitors or to select ones of the capacitors of the array of capacitors to establish a particular capacitance value. The capacitors of the array of capacitors may be of like value or may be of different values, such as would advance simplified response to a digital control word, such as a 1-2-4-8 weighting or a 1-2-2-4 weighting. Similarly, the inductors and micro-electro-mechanical switches may be connected to select a particular inductor of the array of inductors or to select ones of the inductors of the array of inductors to establish a particular inductance value. The inductors of the array of inductors may be of like value or may be of different values, such as would advance simplified response to a digital control word, such as a 1-2-4-8 weighting or a 1-2-2-4 weighting.

Television tuner employing micro-electro-mechanically-switched tuning matrix

An array antenna includes a first ceramic layer and a second ceramic layer. A metal layer is disposed between the first and second ceramic layers. A plurality of radiating elements are mounted on the first ceramic layer, and a plurality of control circuits are mounted on the second ceramic layer. The control circuits are coupled to the radiating elements through a plurality of conductive vias which feed through the metal layer. The array antenna may also include a switch having a plurality of poles formed in the second ceramic layer and coupled to one of the radiating elements through one or more conductive vias. A plurality of phase delay elements may be coupled at a first end to a signal source and coupled at a second end to the respective plurality of poles of the switch to provide phase-delayed signals. A waveguide may also be formed within the ceramic layers. Conductive vias or coaxial transmission lines may be used to connect elements within the array antenna.

Switch structure for antennas formed on multilayer ceramic substrates

Antennas formed using multilayer ceramic substrates

An apparatus for treating neonatal jaundice is in the form of a garment (10, 40) which has semiconductor light sources (14, 214, 314) affixed thereto for radiating toward the 'inside' of the garment when the infant is dressed in the garment. A portable energy source such as batteries (318) or a fuel cell (360) powers the array of light sources. A method according to the invention vests the infant in the garment, and energizes the light sources by coupling a battery to the light sources, or fueling and starting the fuel cell. The therapy is continued for as long as desired or needed.

Therapeutic method and internally illuminated garment for the management

The invention provides apparatuses for detecting light from, for example, closely spaced detection sites. In one embodiment, the invention provides an apparatus for measuring the amount of light emitted from or transmitted through two or more detection sites of a first set of detection sites on a planar substrate while spatially resolving the measurements for each detection site of the first set, the apparatus comprising: for each detection site of the first set, an addressable source of a light beam directed to that detection site at a first angle; and an array detector comprising a plurality of light responsive pixels, wherein for each detection site of the first set there is at least one light responsive pixel that receives light emitted from or transmitted through that detection site at a second angle that can be the same as the first angle.

Massively parallel detection

The invention provides apparatuses for detecting light from, for example, closely spaced detection sites. In one embodiment, the invention provides an apparatus for measuring the amount of light emitted from a first set of two or more detection sites on a planar substrate while spatially resolving the measurements from each first set detection site, the apparatus comprising: a source of a light beam directed towards the planar substrate at a first angle; one or more lenses for focusing light emitted or reflected from each of the first set detection sites and having a second angle having an angle offset from the first angle, onto a unique area of an array detector; and the array detector comprising a plurality of light responsive pixels, wherein for each first detection site there is at least one light responsive pixel that receives light emitted or reflected from that detection site and substantially no cross-talk from another detection site, and wherein substantially none of the light from the light source intersects with the array detector.

A medical probe device comprising a catheter having a stylet guide housing with at least one stylet port in a side thereof and stylet guide means for directing a flexible stylet outward through at least one stylet port and through intervening tissue to targeted tissue. The stylet comprises an electrical central conductor which is enclosed within an insulating or dielectric sleeve surrounded by a conductive layer terminated by an antenna to selectively deliver microwave or radio frequency energy to target tissue. One embodiment includes the electrical conductor being enclosed within a non-conductive sleeve which itself is enclosed within a conductive sleeve in a coaxial cable arrangement to form a microwave transmission line terminated by an antenna. Another embodiment includes a resistive element near the distal end of the stylet which couples the center electrode to an outer conductor to generate joulian heat as electromagnetic energy is applied, such as an RF signal.

Medical probe apparatus with enhanced RF, resistance heating, and

Growing community of inventors

Cherry Hill, NJ, United States of America

Arye Rosen