Florida A&m University

Arvind Bagde

Mandip Singh Sachdeva

Satyanarayan Dev

Thanh Dinh

Keb Mosley-Kellum

Ketankumar Patel

Oluwasevi Salau

A composition, method of treating inflammation or edema, and method of increasing transdermal permeation and flux of at least one cannabinoid is presented. The composition is comprised of at least one cannabinoid, at least one permeation enhancer and at least one hydrophilic polymer. Administration of a therapeutically effective amount of this composition of can be used to treat both inflammation and edema in a patient as well as increasing transdermal permeation and flux of the at least one cannabinoid.

Method of transdermal delivery of cannabinoid compositions

Described herein relates to a multi-component adaptor assembly including a resin reservoir adaptor disposed on a printing surface of a preexisting additive manufacturing device, and including a build platform adaptor secured to a translatable arm of the preexisting additive manufacturing device. The resin reservoir adaptor is used to modify an existing resin reservoir by creating one or more smaller reservoirs within the larger housing, thereby reducing an amount of resin stored within the device to reduce resin waste. Moreover, the rotating and/or sliding build platform adaptor is designed to selectively contact one or more of the reservoirs of the resin reservoir adaptor, thereby selectively printing components of an additive manufactured process. The multi-component adaptor assembly allows for additive manufacturing projects using less resin with fewer waste products; simultaneous printing of identical structures; and the selective printing of different components of a structure during a single printing cycle.

Adaptor for additive manufacturing device that improves printing efficiency by reducing resin usage

A biocompatible resin composition that is used in the manufacture of a dissolvable microneedle that is used for the transdermal delivery of one or more active pharmaceutical ingredients to a subject. The biocompatible resin composition includes lithium phenyl-2,4,6-trimethylbenzoylphospinate, water, and poly(ethylene glycol) diacrylate (molecular weight 550), and may include methacrylated hyaluronic acid, that is capable of forming a structurally stable microneedle patch. The microneedle patch is formulated with the biocompatible resin composition using a continuous, one-step process utilizing additive manufacturing. Once manufactured, the microneedle patches are formulated to adhere to an outer layer of a subject's skin. Once administered to the subject, the microneedle compositions create microscopic pathways into the subject's subdermal layers to deliver one or more active agents to the subject, such as to the subject's bloodstream.

Biocompatible resin composition and method of manufacturing dissolvable microneedles for transdermal delivery using biocompatible resin

A multi-component adaptor assembly including a resin reservoir adaptor disposed on a printing surface of a preexisting additive manufacturing device, and including a build platform adaptor secured to a translatable arm of the preexisting additive manufacturing device. The resin reservoir adaptor is used to modify an existing resin reservoir by creating one or more smaller reservoirs within the larger housing, thereby reducing an amount of resin stored within the device to reduce resin waste. Moreover, the rotating and/or sliding build platform adaptor is designed to selectively contact one or more of the reservoirs of the resin reservoir adaptor, thereby selectively printing components of an additive manufactured process. The multi-component adaptor assembly allows for additive manufacturing projects using less resin with fewer waste products; simultaneous printing of identical structures; and the selective printing of different components of a structure during a single printing cycle.

A continuous process for preparing a solid lipid nanoparticle of ibuprofen utilizing hot melt extrusion which avoids additional steps such as high-pressure homogenization, ultrasonication, or solvent evaporation. The continuous process includes preparing a pre-emulsion comprising a lipid, and continuously processing the pre-emulsion through a hot melt extruder device.

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Tallahassee, FL, United States of America

Arvind Bagde