Thermo Fisher Scientific Baltics Uab

Fermentas Uab

Arunas Lagunavicius

Lolita Zaliauskiene

Arvydas Janulaitis

Ausvydas Vareikis

Ricardas Makuska

Sarunas Zigmantas

Daiva Tauraite

Leonas Grinius

Laurynas Riauba

Richard Makuska

Ula Bernadisiute

Jurgita Barkauskaite

Zivile Kiveryte

Vilma Zimbaite-Ruskuliene

Agne Savaneviciute

A composition having nucleic acid polymerase activity, which comprises an active nucleic acid polymerase and an excess amount of a non-functional mutant nucleic acid polymerase protein, wherein the non-functional mutant nucleic acid polymerase protein stabilizes the active nucleic acid polymerase against loss of polymerase activity.

Polymerase compositions and uses

A composition comprising a polycationic agent and a polyanionic agent, and kits comprising the composition, is provided. In embodiments, the polyanionic agent is a nucleic acid and the polycationic agent is a modified polyalkyleneimine polymer.

Delivery agent

A composition and method for delivering a peptide or protein into a cell comprising a polycationic agent and a polyanionic agent, wherein the polyanionic agent comprises an inorganic polyphosphate or a polyoxometalate and/or the polycationic agent comprises a polyalkyleneimine.

The present invention relates to the field of thermostable enzymes, methods for their inactivation, and related uses, kits and reagents. In particular, the invention relates to a method for reversible inactivation of thermophilic enzymes by chemical modification under aqueous or non-aqueous conditions.

Inactivation method

The present invention relates to a polyalkyleneimine polymer having a repeat unit comprising a hydrophilic group, agents containing the same and methods for their use.

Transfection reagent

A composition and method comprising a polycationic agent and a polyanionic agent for delivering a peptide or protein into a cell.

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Vilnius, Lithuania

Arunas Lagunavicius