University of Florida Research Foundation, Incorporated

Aruna S Jaiswal

Satya Narayan

David A Ostrov

Sukwon Hong

The instant invention describes biisoquinoline compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders, or affect cell differentiation, dedifferentiation or transdifferentiation.

Biisoquinoline compounds and methods of treatment

The invention features compositions and methods that are useful for the treatment of neoplasia (e.g., pancreatic cancer, colon cancer, brain cancer) by increasing DNA damage, reducing nucleotide synthesis, and reducing base excision repair (BER).

Therapeutic combinations for use in neoplasia

The invention features compositions and methods that are useful for the treatment of neoplasia by reducing base excision repair (BER). Such compositions are useful, for example, for enhancing the efficacy of known chemotherapeutics, such as DNA alkylating agents. In particular, the invention features agents that mimic the interaction of APC with pol-&#x3b2;. Such agents reduce the activity of long patch- and single nucleotide-base extension repair pathways.

Compositions and methods of treating neoplasia

The invention features compositions and methods that are useful for the treatment of neoplasia (e.g., breast cancer) by increasing DNA damage and reducing base excision repair (BER).

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Gainesville, FL, United States of America

Aruna S Jaiswal