Florida A&m University

University of Michigan

The United States Government As Represented by the Department of Veterans Affairs

Wayne State University

Arun Rishi

Mandip Singh Sachdeva

Ketankumar Patel

Scott D Larsen

A solid self-micro/nano emulsifying formulation comprising CARP-1 functional mimetics (CFM; e.g., CFM-4.16 or CFM-4.17) for oral administration, and methods of fabrication and use thereof to treat cancer (e.g., breast cancer, triple negative breast cancer, resistant lung cancer, and non-resistant lung cancer) and reduce tumor volume. Solid self-micro/nano emulsifying formulation of CFM compounds was found to have significantly enhanced drug loading, aqueous solubility, and oral bioavailability of the formulation.

Self-emulsifying formulation of CARP-1 functional mimetics

The invention provides compounds of formula I: and salts thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating cancer using compounds of formula I. 

Therapeutic compounds and methods

Growing community of inventors

Detroit, MI, United States of America

Arun Rishi