The State University of New York

Children's Medical Center Corporation

Arun Richard Chandrasekaran

Wesley Philip Wong

Kenneth Anders Halvorsen

Clinton H Hansen

Mounir Ahmad Koussa

Provided herein are nucleic acid-based nanoswitches that can detect specific nucleic acids and other analytes types by for example a simple gel electrophoresis readout. Binding of the target to the nanoswitches induces a conformation change from a linear, open conformation to a looped, closed conformation. These nanoswitches may be used in diagnostic assays such as nucleic acid-based diagnostic assays, to detect, measure and/or purify a variety of targets including low abundance targets.

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Albany, NY, United States of America

Arun Richard Chandrasekaran