Piramal Life Sciences Limited

Hoechst Aktiengesellschaft

Arun Kumar Jain

Bansi Lal

Swati Bal-Tembe

Usha Ghosh

Tulsidas More

Andreas Gerhard Weichert

Jan-Robert Schwark

Sapna Parikh

Ravindra Dattatraya Gupte

Anil Vasantrao Ghate

Rao Venkata Vadlamudi

Anil Ghate

Nirogi Venkata Ramakrishna

Jacqueline Trivedi

Guanidine derivatives having a condensed tricyclic ring of formula 1: are disclosed, wherein U is C(O), CRR, O, NRor S(O); V is CRRor NR; W is S(O); wherein Ris H, alkyl, cycloalkyl, alkenyl or aralkyl; Ris H, alkyl, OH, ORor OCOR, and m is the integer 0, 1 or 2; R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein with the proviso that at least one of R1, R2, R3, R4, R5, R6, R7 or R8 is guanidino or guanidinocarbonyl. These derivatives are sodium-proton exchange inhibitors and are useful as medicaments for the treatment of, for example, organ disorders associated with ischemia and reperfusion, cardiac arrhythmia, cardiac hypertrophy, hypertension, cell proliferative disorders and diabetes.

Tricyclic guanidine derivatives as sodium-proton exchange inhibitors

Guanidine derivatives having a condensed tricyclic ring of formula 1: are disclosed, wherein U is C(O), CRR, O, NRor S(O); V is CRRor NR; W is S(O); wherein Ris H, alkyl, cycloalkyl, alkenyl or aralkyl; Ris H, alkyl, OH, ORor OCOR, and m is the integer 0, 1 or 2; R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein with the proviso that at least one of R1, R2, R3, R4, R5, R6, R7 or R8 is guanidino or guanidino carbonyl. These derivatives are sodium-proton exchange inhibitors and are useful as medicaments for the treatment of, for example, organ disorders associated with ischemia and reperfusion, cardiac arrhythmia, cardiac hypertrophy, hypertension, cell proliferative disorders and diabetes.

Substituted Indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them:

Substituted indanylidineacetylguanidines, processes for their

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Mumbai, India

Arun Kumar Jain