Norcliff Thayer Inc.

Lewis/howe Company

Arun K Mitra

Robert G Flynn

Stable aqueous thixotropic compositions containing from about 16 to 24% by wt./vol. of magnesium hydroxide are obtained by using an anionic polymer, a stabilizing or thixotropy producing agent and a thinning or fluidizing agent in a specific order of addition.

Concentrated magnesium hydroxide preparations

Provided is a method and lozenge composition which permits antacid and simethicone to be in intimate contact while still maintaining unimpaired defoaming activity of simethicone.

Simethicone antacid lozenge

A controlled antacid delivery form having an acid neutralizing component in a matrix including a gel-forming, swelling agent and a water insoluble lipid material. These materials are mixed with the antacid component, together with a large amount of sweet excipient, and compressed at high pressure to provide an antacid lozenge which dissolves very slowly in the mouth. A method for controlled antacid delivery wherein the controlled antacid delivery form is slowly dissolved in the mouth and neutralizes the stomach acid over a long period of time with surprising little antacid, while bathing the esophageal lining with antacid. When the controlled antacid delivery form includes a mixture of antacids having different reactivities towards acid, said method provides for substantially complete utilization of each component.

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St. Louis, MO, United States of America

Arun K Mitra