I2 Pharmaceuticals, Inc.

Sea Lane Biotechnologies, LLC

Arun K Kashyap

Ramesh Bhatt

Lawrence C Horowitz

Charles H Hannum

Li Xu

Michael D Horowitz

Aaron L Kurtzman

Sihong Zhou

Ryann E O'Neil

Lawrence Horowitz

Michael Horowitz

Ryann E O' Neil

The present invention concerns methods and means for identifying, producing, and engineering neutralizing antibodies against influenza A viruses, and to the neutralizing antibodies produced. In particular, the invention concerns neutralizing antibodies against various influenza A virus subtypes, and methods and means for making such antibodies.

Neutralizing molecules to influenza viruses

Embodiments concern constructs comprising surrogate light chain sequences. In particular, embodiments concern constructs that can bind to DR4 and/or DR5 and aspects relating to such constructs and their use.

Surrogate binding proteins which bind DR4 and/or DR5

The present invention concerns methods and means for identifying, producing, and engineering neutralizing molecules against influenza A viruses, and to the neutralizing molecules produced. In particular, the invention concerns neutralizing molecules against various influenza A virus subtypes, including neutralizing antibodies against H5 and/or H3 and/or H1, such as, for example all of H1, H3, and H5 subtypes, and methods and means for making such molecules.

Neutralizing molecules to viral antigens

The present invention concerns donor-specific antibody libraries derived from a patient donor who has suffered from, or is suffering from one or more diseases discussed herein. The present invention also concerns the method of making and using the donor-specific antibodies. The present invention further concerns the neutralizing antibodies obtained from the donor-specific antibody libraries and the methods of using these antibodies for the prevention/treatment of human disease.

Donor specific antibody libraries

Growing community of inventors

San Francisco, CA, United States of America

Arun K Kashyap