Purdue Research Foundation

University of Illinois

Oklahoma Medical Research Foundation

Kumamoto University

Comentis, Inc.

The United States of America, As Represented by the Secretary, Department of Health and Human Services

University of California

Hiroaki Mitsuya

National University Corporation Kumamoto University

National University Corporation of Kumamoto University

Arun K Ghosh

Jordan J N Tang

Geoffrey M Bilcer

Thippeswamy Devasamudram

Andrew Mesecar

Hui Lei

Chunfeng Liu

Margherita Brindisi

Cuthbert D Martyr

John W Erickson

Monika Yadav

Sudha V Ankala

Yves Pommier

Bruno D Chapsal

Sergei V Gulnik

Garth L Parham

Chun-Xiao Xu

Prasanth Reddy Nyalapatla

Lisa M Swanson

Emilio Leal Cardenas

Jordan J Tang

Xiaoming Xu

Xinli Lin

Lin Hong

Gerald Koelsch

Sofiya Yashchuk

Gabriel Fenteany

Nagaswamy Kumaragurubaran

Audha Ankala

Kevin McHenry

Xiangping Huang

Sarosh Anjum

Luke A Kassekert

Deborah Downs

Shoutian Zhu

Marcus Noetzel

Venkateswararao Kalapala

Sofiya Leshchenko

Jianfeng Li

Dana Shahabi

Melissa Jurica

Shivaji Markad

Satish Kovela

Sean Fyvie

Yasuhiro Koh

Venkateswara Rao Kalapala

John C Lilly

Yongwei Zhang

Venkateswara Kalapala Rao

Inhibitors of SARS-CoV-2 (COVID), pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome.

Compounds for the treatment of SARS

Compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof are disclosed. The compounds HIV-protease and, as a result, are useful in the treatment of HIV infection.

HIV-1 protease inhibitors and uses thereof

The disclosure relates to a method of synthesizing the high-affinity, non-petidyl ligand (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-ol, which is useful in the synthesis of various compounds, such as HIV-1 protease inhibitors.

Method of synthesizing (3S,3AR,5R,7AS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-ol

Described herein are compounds of the formulae (I)-(III) as well as pharmaceutical compositions comprising such compounds and methods for using such compounds/pharmaceutical compositions for treating Alzheimer's disease.

BACE1 inhibitors for the treatment of Alzheimer's disease

Embodiments provide, among other compounds, a family of compounds that can be used as therapeutic anti-cancer agents, methods for using such compounds to treat cancer, and methods of making such compounds.

Anti-cancer agents and preparation thereof

Described herein are compounds of the formulae (I)-(III) and (Ia)-(IIIa) and pharmaceutically acceptable salts, isomers, mixture of isomers, crystalline forms, non-crystalline forms, hydrates, or solvates thereof, as well as methods using compounds of the formulae (I)-(III) and (Ia)-(IIIa) to, among other things, treat cancer.

Herboxidiene derivatives and uses thereof

Bis-amide inhibitors of SARS-CoV-2 (COVID); pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome.

Various embodiments relate to a compound of the formula (I) and (II), wherein X, X, X, X, and R-Rare defined herein, as well as pharmaceutical compositions comprising compounds of the formula (I) and/or (II) and methods of treating an HIV infection comprising administering a therapeutically effective amount of one or more compounds of formula (I) and/or (II), or a pharmaceutical composition comprising compounds of the formula (I) and/or (II), to a patient in need thereof.

Tricyclic P2-ligand containing potent HIV-protease inhibitors against HIV/AIDS

Described herein are compounds of the formulae (I), (Ia), (Ib), and (II) and pharmaceutically acceptable salts, isomers, mixture of isomers, crystalline forms, non-crystalline forms, hydrates, or solvates thereof, as well as methods of making and using compounds of the formulae (I), (Ia), (Ib), and (II) to, among other things, treat HIV/AIDS.

Macrocyclic HIV-1 protease inhibitors and uses thereof

Described herein are compounds of the formula (I)-(III) (or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof), as well as methods of making and using compounds of the formula (I)-(III) to, among other things, treat various forms of cancer.

Callyspongiolide, analogs thereof and uses thereof

Various embodiments relate to a compound of the formula (I): wherein X, X, R&#x2014;Rand Rare defined herein, as well as pharmaceutical compositions comprising compounds of the formula (I) and methods of treating an HIV infection comprising administering a therapeutically effective amount of one or more compounds of formula (I), or a pharmaceutical compositions comprising compounds of the formula (I), to a patient in need thereof. 

Growing community of inventors

West Lafayette, IN, United States of America

Arun K Ghosh