Albert Einstein College of Medicine

Arturo Casadevall

Ekaterina Dadachova

Joshua D Nosanchuk

Harris Goldstein

Jacqueline Michele Achkar

Claudia Gravekamp

Ruth A Bryan

Nareen Abboud

Antonio Nakouzi

Aharona Glatman-Freedman

Rafael Prados-Rosales

Rafael Ovalle

Anke Ziegenbalg

Methods and compositions are provided for alleviating and/or preventing one or more side effects associated with exposure to radiation in a subject exposed to radiation or at risk for exposure to radiation comprising oral administration to the subject of an amount of an edible source of melanin effective to alleviate a side effect associated with radiation.

Oral administration of melanin for protection against radiation

A method of treating a tumor in a subject, or reducing or preventing metastasis of a tumor in a subject, is provided comprising administering to the subject an amount of a bacteria labelled with, or comprising, one or more radionuclides so as to treat the tumor in the subject, or so as to reduce or prevent metastasis of the tumor in the subject. Radiobacteria-containing compositions and pharmaceutical compositions are also provided.

Radiobacteria for therapy of cancer

The present invention relates to methods and kits for detecting active tuberculosis infection in a subject using serological techniques and a first agent capable of binding an IgG, IgA and/or IgM directed to the first protein present in or on amembrane vesicle or aCalmette-Guerin (BCG) membrane vesicle. Also provided are methods of treating a subject with an active tuberculosis disease.

Serologic test for the rapid diagnosis of active tuberculosis

This present invention provides methods of enhancing the growth of a microorganism or plant by increasing its melanin content and exposing it to radiation, and methods of using melanized microorganisms to contain or exclude radiation.

Radiosynthesis as an alternative energy utilization process in melanized organisms and uses thereof

This invention provides melanin nanoshells and their use for protection against radiation, particularly ionizing radiation, and electronic pulses, and methods of making materials comprising melanin nanoshells.

Melanin nanoshells for protection against radiation and electronic pulses

The present invention provides a purified peptide comprising at least one of the sequences LKQKSSNSRKKRSTS (SEQ ID NO:1), or VKNKRTFLSPWISNI (SEQ ID NO:2) as well as a vaccine, a method to protect or treat an animal from anthrax toxin, a method of making a vaccine and the use of the peptide. The present invention also provides a monoclonal antibody that specifically binds to a peptide sequence comprising at least one of the following peptide sequences: LKQKSSNSRKKRSTS (SEQ ID NO:1), or VKNKRTFLSPWISNI (SEQ ID NO:2) as well as a method to protect or treat an animal from anthrax toxin, a method of making a vaccine, a pharmaceutical composition, a method of making a pharmaceutical composition, and the use of the monoclonal antibody.

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This invention provides methods for treating infections in a subject which comprise administering to the subject an amount of a radiolabeled antibody effective to treat the infection, wherein the antibody specifically binds to the agent causing the infection. The invention also provides compositions and methods of making compositions comprising radiolabeled antibodies for the treatment of infections.

Methods of applying ionization radiation for therapy of infections

This invention provides methods for imaging and/or treating a tumor in a subject which comprise administering to the subject an amount of a radiolabeled antibody effective to image and/or treat the tumor, where the radiolabeled antibody binds to a cellular component released by dying tumor cells. This invention also provides methods for imaging and/or treating melanin-containing melanomas in a subject which comprise administering to the subject an amount of a radiolabeled anti-melanin antibody effective to image and/or treat the melanoma. The invention also provides compositions and methods of making compositions comprising radiolabeled antibodies for imaging and treating tumors, including melanin-containing melanomas.

Radiolabeled antibodies for treatment of tumors

The present invention provides for monoclonal antibodies, the hybridoma cell lines which produce these antibodies, and the use of such monoclonal antibodies in the detection of More specifically, the present invention provides for monoclonal antibodies that react with surface epitopes of and the use of these monoclonal antibodies for detecting and diagnosing . Also provided by the present invention is a modified ELISA assay for detection of microorganisms, and a modified ELISA assay employing the monoclonal antibodies of the present invention for detecting

Monoclonal antibodies to mycobacterium tuberculosis and a modified ELISA assay

The present invention provides a method for treating a subject infected with a mammalian pathogenic fungus which uses melanin in virulence, by administering to the subject an amount of glyphosate effective to treat the infection. The present invention further provides a method for inhibiting proliferation of a mammalian pathogenic fungus which uses melanin in virulence, by contacting the fungus with an amount of glyphosate effective to inhibit the proliferation of the fungus. Additionally, the present invention further provides a method for inhibiting melanogenesis in a microorganism which produces melanin, by contacting the microorganism with an amount of glyphosate effective to inhibit melanogenesis in the microorganism.

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Pelham, NY, United States of America

Arturo Casadevall