Indena S.p.a.

Arturo Battaglia

Ezio Bombardelli

Gabriele Fontana

Andrea Guerrini

Carla Manzotti

Maria Grazia Allegri, Legal Representative

Cristian Samori

Eleonora Baldelli

Alessandro Pontiroli

Paolo Dambruoso

Giacomo Carenzi

Donato Pocar

Maria Luisa Gelmi

Bruno Danieli

Cristian Samori′

Samanta Cimitan

Pocar Donato

Novel camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.

Camptothecin derivatives with antitumor activity

A general process for the functionalization at the 14-position of 13-ketobaccatin derivatives of formula I to give derivatives of formula II wherein the substituents are as defined in the disclosure. The conversion of compounds of formula II in compounds of formula III, wherein the substituents are as defined in the disclosure, is also described. 

Taxane derivatives functionalized at the 14-position and a process for the preparation thereof

The present invention relates to an efficient procedure for the synthesis of deserpidine (Ia), starting from reserpic acid lactone (II) via the intermediate 11-O-demethyl reserpic acid lactone (III). 

Process for the semisynthesis of deserpidine

A process for the preparation of 14&#x3b2;-hydroxy-baccatin III-1,14-carbonate useful for the preparation of novel taxane derivatives with antitumor activity.

Process for the preparation of the 14&#x3b2;-hydroxy-baccatin III-1,14-carbonate

Taxane derivatives of formula (I) in which: R is trifluoromethyl, phenyl, 2-furyl, 2-thienyl; Ris t-butoxycarbonyl or benzoyl; Ris hydroxy; Ris hydrogen or, together with R, it forms the residue of a cyclic carbonate of formula: II with the proviso that when R3 is hydrogen, R is different from phenyl. Compounds of formula (I) have antitumor activity 

C-2' methylated derivatives of paclitaxel for use as antitumour agents

A process for the preparation of paclitaxel starting from 10-deacetylbaccatine III.

Process for the preparation of paclitaxel

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Bologna, Italy

Arturo Battaglia