Vanderbilt University

Artur W Wamil

Carl G Hellerqvist

Barbara D Wamil

Neural injury may be advantageously treated with CM101, a polysaccharide toxin isolated from Group B &bgr;-hemolytic Streptococcus bacteria. CM1O1 treatment aids in the re-establishment of neuronal connectivity, at least partially inhibits scar formation, and increases the probability of survival during the critical period following injury to the central nervous system. Preexisting neural injuries having scar tissue are ameliorated by surgical excision of the scar tissue in conjunction with administration of CM101.

Facilitation of repair of neural injury with CM101/GBS toxin

Neural injury of the type resulting from trauma or surgery may be advantageously treated with a polysaccharide toxin derived from Group B .beta.-hemolytic Streptococcus (GBS) bacteria. Additionally, diseases characterized by neuronal degeneration or impairment of neuronal connectivity, such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis may be treated with the GBS toxin. The GBS toxin is administered to the patient before, during, or after infliction of the neural injury and acts by minimizing gliosis and promoting the reestablishment of neuronal connectivity.

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Nashville, TN, United States of America

Artur W Wamil