Other

Upm-kymmene Corporation

Orion-yhtyma Oy

Oy Polymer Corex Kuopio Ltd.

Orion Corporation

Alko Group Ltd.

Arto Olavi Urtti

Timo Petteri Paronen

Soili Hellevi Peltonen

Marjo Yliperttula

Patrick Laurén

Tomi Jarvinen

Kari Luukko

David W Pate

Petter Somersalo

Timo Laaksonen

Heli Paukkonen

Tiina Hakkarainen

Vili-Veli Auvinen

Leena Johanna Nakari

Antti Valjakka

Janne Ahonen

Markus Nuopponen

Arto J Karjalainen

Risto A Lammintausta

Raimo E Virtanen

Lasse Lehtonen

Arto Merivaara

Saila Antila

Heikki Joensuu

Yan-Ru Lou

Ewen MacDonald

Outi Monni

Jouni Hirvonen

Anne Mäkelä

Piia-Riitta Karhemo

Maija Elina Heikkil&auml;

Raili Koivuniemi

Thomas Yorio

Melina Malinen

Pekka Suhonen

Liisa Kanninen

Esko Pohjala

Hannu Hanhijarvi

Kirsti Johanna Niklander

Pekka Peura

Riina Harjumäki

Marja R Sutinen

Jani-Emanuel Vuorenpaa

Kristiina Jarvinen

Kristina Jarvinen

Mingwei Li

Mikko Kunnari

Kristiina Haasmaa

Jani Vuorenp&auml;&auml;

The present disclosure relates to method for drying hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing polyethylene glycol, providing trehalose, mixing the hydrogel, the polyethylene glycol and the trehalose to obtain a mixture, and freeze drying the mixture to obtain a dried hydrogel comprising nanofibrillar cellulose. The present disclosure relates to a freeze-dryable hydrogel comprising nanofibrillar cellulose, to a freeze-dried hydrogel comprising nanofibrillar cellulose, and to a medical hydrogel comprising nanofibrillar cellulose and one or more therapeutic agent(s).

Method for drying hydrogel comprising nanofibrillar cellulose and a dried hydrogel comprising nanofibrillar cellulose

The present disclosure provides a method for freeze-drying cells in a hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing cells, combining the cells and the hydrogel comprising nanofibrillar cellulose to form a cell system, and freeze drying the cell system to obtain dried cells in a hydrogel comprising nanofibrillar cellulose. The present disclosure also provides a freeze-dried hydrogel comprising nanofibrillar cellulose and cells.

Method for freeze-drying cells in a hydrogel comprising nanofibrillar cellulose and freeze-dried cells in an aerogel comprising nanofibrillar cellulose

The present invention relates a method for chemical testing, comprising culturing cells in a first plant-derived nanofibrillar cellulose (NFC) hydrogel to obtain in vivo like cells; exposing the in vivo like cells to a test chemical; optionally within another plant-derived NFC hydrogel; incubating the exposed in vivo like cells; detecting during or after incubating, the impact of the test chemical on the in vivo like cells by at least one detection; and removing the plant-derived NFC hydrogel at least once at any stage after obtaining the in vivo like cells and before at least one detection used for detecting the impact of the test chemical on the in vivo like cells. The invention further relates to the use of plant-derived NFC hydrogel in a method for chemical testing, the use of in vivo like cells obtained by culturing cells in plant-derived NFC hydrogel for chemical testing and to a kit for chemical testing comprising plant-derived NFC hydrogel, instructions and a cell or test chemical library.

Plant-derived nanofibrillar cellulose hydrogel for cell culture and chemical testing

The present invention relates to an electrode detector, which comprises a contact electrode part adjustable to tissue, or being in touch with it and which contact electrode part is for monitoring biopotential or other physical magnitude, a conducting wire () attached to the contact electrode part, electroconductive material, non-electroconductive material and electronics processing the signal. The electrode detector in accordance with the invention comprises a ball-shaped or almost ball-shaped contact electrode part, monitoring biopotential or some other physical magnitude, the covering part of which contact electrode part is made of non-toxic material to tissue and some electroconductive part of which has been galvanically or capacitively or indirectly through an electronic circuitry in the contact electrode part itself connected to the electroconductive inner part of a flexible conducting wire while its covering part is made of material that is non-toxic to tissue and insulating electricity, and attaching part of which has been connected or may be connected galvanically, non-galvanically or indirectly through the electronic circuitry in the attaching part to the conducting wire of the electrode detector and which may be anchored with external attaching elements/attaching material in it or some other external attaching elements/materials near the subject to be monitored.

Electrode detector for monitoring biopotential on tissue

The present invention relates to a visual stimulator, which comprises a light stimulation source, a regulable attenuator of light, mirrors for reflecting light and light detectors. The visual stimulator in accordance with the invention comprises a mirror chamber and a mirror tube constructed of mirrors in which the reflecting points of the mirrors form various angles with respect to each other, and which have been connected to each other such that light beams disperse from the mirror tube to the mirror chamber without hindrance regardless of the location of the object to be examined or a part of it in the mirror chamber and though the location of the object or a part of it would vary in certain limits in the mirror chamber, and that to one end of the mirror tube, viewed away from the mirror chamber a light stimulation source has been directed.

Visual stimulator

The invention relates to a hydrophobic polymer dispersion and a solvent-free process for the preparation thereof. According to the invention, the dispersion contains starch ester together with dispersion admixtures known as such. According to the process, the polymer is first mixed with a plasticizer in order to obtain a plasticized polymer blend. The plasticized polymer blend is then mixed with dispersion admixtures and water at an elevated temperature so as to form a dispersion. The plasticizing of the polymer and the dispersion of the mixture in water can be performed in an extruder. The obtained dispersion is homogenized in order to improve its stability. The dispersion obtained by the invention can be used to coat paper or board, as a primer or a component in paint or labeling adhesives, and it is also suitable for the production of cast films and as a binder in materials based on cellulose fibers, as well as for coating medicinal preparations.

Hydrophobic polymer dispersion and process for the preparation thereof

Transdermal administration of levosimenden or (&minus;)-&lsqb;&lsqb;4-(1,4,5,6-tetahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazono&rsqb;propanedinitrile or a pharmaceutically acceptable salt thereof is disclosed. Transdermal preparations of levosimenden can be in the form of e.g. ointment, emulsion, lotion, solution, gel, cream, patch or transdermal delivery device including iontophoretic device.

Transdermal compositions containing levosimendan

Anandamide analog compositions and method of treating intraocular

The present invention is related to a novel type of composition with modifiable properties and suitable for controlled release of active ingredients in industrial use. The composition contains an active ingredient and starch acetate in the form of a compact. More specifically the invention relates to active ingredients such as solid dosage forms of drugs, especially compacts and tablets. In these compacts starch acetate with distinct substitution degrees are used. The starch acetate makes the process industrially feasible with good flowability and facilitates the formation of firm tablets. Starch acetate enables the controlled release of the active ingredient. The invention also discloses method for the preparation of the composition as well as its use.

Starch acetate composition with modifiable properties, method for

The present invention is related to a composition for pH dependent or pH regulated controlled release of active ingredients especially drugs. The composition consists of a compactible mixture of the active ingredient and starch molecules substituted with acetate and dicarboxylate residues. The preferred dicarboxylate acid is succinate. The average substitution degree of the acetate residue is at least 1 and 0.2-1.2 for the dicarboxylate residue. The starch molecules can have the acetate and dicarboxylate residues attached to the same starch molecule backbone or attached to separate starch molecule backbones. The present invention also discloses methods for preparing said starch acetate dicarboxylates by transesterification or mixing of starch acetates and starch dicarboxylates respectively.

Composition for pH dependent controlled release of active ingredients

Anandamides useful for the treatment of intraocular hypertension, as well as ophthalmic compositions comprising the same and a cyclodextrin, and methods of use of these compounds to treat intraocular hypertension.

Anandamides useful for the treatment of intraocular hypertension,

Peroral drug delivery system

The object of the invention are bispilocarpates useful in the treatment of glaucoma and having the formula ##STR1## wherein A) Y is hydrogen or the acyl group ##STR2## and W is the group --O--A--O--Z--Y', wherein Y' is hydrogen or the acyl group ##STR3## the groups R and R' having different meanings and may be the same or different and A is an aliphatic, aromatic or heterocyclic bridging group, and --Z--Y' is ##STR4## or B) W is OR, wherein R has the same meaning as above, Y is ##STR5## where R' has the same meaning as above, B means the same as A and Z'--OR' is ##STR6## or C) W and Y together mean ##STR7## where the symbols have the same meanings as above.

Bispilocarpic acid ester derivatives and process for their preparation

Compounds of formula: ##STR1## where X is --CH.sub.2 --, --CH(CH.sub.3)--, --CHR.sub.3 --CH.sub.2 -- or --CR.sub.3 .dbd.CH-- and R.sub.1, R.sub.2 and R.sub.3, which can be the same or different, are each H or CH.sub.3 or a stereoisomer or pharmaceutically acceptable salt thereof, and pharmaceutical compositions containing them, are useful for lowering intraocular pressure in a mammal, e.g. in the treatment of glaucoma.

Compositions and their use in lowering intraocular pressure

Growing community of inventors

Kuopio, Finland

Arto Olavi Urtti