Sky Medical Technology Limited

Queen Mary & Westfield College

University of London

First Water Limited

Edixomed Limited

Barts Health National Health Service Trust

Barts and the London National Health Service Trust

Arthur Tudor Tucker

Duncan Shirreffs Bain

Bernard Ross

Hugh Semple Munro

Christopher Barry Wood

Nigel Benjamin

Nicholas David Boote

Joanne Ellen Stewart

Gregory James Firth

Charles Hinds

Robert Allaker

Methods and devices are described for preventing diastolic flow reversal and/or reducing peripheral vascular resistance in a patient. Also described are methods of cosmetic treatment, and methods of promoting delivery of therapeutic agents or contrast agents to bones and related tissues.

Prevention and treatment of diastolic flow reversal

A method and device for increasing microcirculation in the lower limb are described. The device includes a means for immobilizing the limb, for example a plaster cast, and an electrical stimulation device, which applies electrical stimulation to opposed leg muscles such that antagonistic and agonistic muscle groups contract near simultaneously, resulting in near isometric contraction. The combination of this contraction and the leg restraint have been found to markedly increase blood circulation and in particular microcirculation in the limb.

Device for increasing microcirculation

The invention relates to a method and device for neuromuscular stimulation of one or more muscles, or muscle groups, with one or more beneficial effects selected from increasing arterial, venous and capillary blood flow, increasing flux of interstitial fluid and lymphatic drainage, increasing tissue oxygenation, enhancing heat distribution, enhancing the distribution of pharmaceutical products, and enhancing performance and recovery from exertion in horses.

Device for augmenting blood flow, tissue perfusion and fluid distribution by neuromuscular stimulation in horses and other non-human mammals

The present invention provides a system comprising: (i) a layer containing a nitrite; and (ii) a hydrogel that contains hydrogen ions; wherein the layer containing a nitrite and/or the hydrogel comprises a pharmaceutically active agent. The invention also provides the use of a system of the invention in medicine, and in the treatment of pain.

Transdermal delivery system

Treatment

The present invention provides a system comprising: (i) a layer containing a nitrite; and (ii) a hydrogel that contains hydrogen ions. The invention also provides the use of a system of the invention for the treatment of a condition associated with tissue ischaemia or a wound and the use of a system of the invention in combination with an anaesthetic for the treatment or prevention of pain.

Dressing system

A device for identifying appropriate nerve stimulation points on a patient is described, for use with an electrical stimulation device. In a first embodiment, the device includes electrodes located on a flexible substrate, a conductive gel layer overlying the electrodes, and a partially conductive removable cover overlying the gel layer. The device may be operated initially with the cover in place to allow reduced stimulation to identify a suitable nerve stimulation point. The cover may then be removed, and the device operated at the identified point. The cover may include perforations allowing the gel to contact the patient; or may be a sacrificial gel layer.

Nerve locator

The use of liquid formulations in the preparation of a medicament for the prevention and treatment of oral, gastric and digestive infections and in particular for the prevention of ventilator associated pneumonia as well as liquid enteral and parenteral tube feeding compositions. The feeding compositions are suitable for use in the prevention of ventilator associated pneumonia.

Therapeutic composition and use

The present invention provides a method and device for reduction of or treatment of deep vein thrombosis (DVT), the method comprising causing isometric stimulation of the leg muscles to promote blood flow. Other embodiments provide treatment for other circulatory disorders of the lower limbs and/or the systemic circulation.

Medical device for isometric stimulation to improve blood flow

A pharmaceutically delivery system is described comprising a pharmaceutically active agent and acidified nitrite as an agent to produce local production of nitric oxide at the skin surface. The dosage form may be in any pharmaceutically acceptable carrier means and comprises an acidifying agent adapted to reduce the pH at the environment. In one embodiment, a barrier consisting of a membrane allows diffusions of the anaesthetic and nitrite ions while preventing direct contact of the skin and acidifying agent.

Transdermal pharmaceutical delivery composition

A pharmaceutically delivery system and method of use therefor are described comprising a pharmaceutically active agent and acidified nitrite as an agent to produce local production of nitric oxide at the skin surface. The dosage form may be in any pharmaceutically acceptable carrier means and comprises an acidifying agent adapted to reduce the pH at the environment. In one embodiment, a barrier consisting of a membrane allows diffusions of the anaesthetic and nitrite ions while preventing direct contact of the skin and acidifying agent.

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London, United Kingdom

Arthur Tudor Tucker