Lexicon Genetics Corporation

Lexicon Pharmaceuticals, Inc.

Baylor College of Medicine

Lexicon Graphics Incorporated

Arthur T Sands

Brian Zambrowicz

Glenn A Friedrich

C Alexander Turner, Jr

Gregory Donoho

Michael C Nehls

Alejandro Abuin

John Scoville

Erin Hilbun

Allan Bradley

D Wade Walke

Brian Mathur

Stan Lilleberg

Yi Hu

Nathaniel L Wilganowski

James Alvin Kieke

David George Potter

Sigrid Wattler

Michael Nehls

Alex Turner

H Earl Ruley

Marie Harras

Rob Burgess

Methods of treating pulmonary hypertension are disclosed. Particular methods comprise the administration of a tryptophan hydroxylase inhibitor and a prostacyclin. Pharmaceutical formulations are also disclosed.

Methods of treating pulmonary hypertension

Methods of treating pulmonary hypertension are disclosed. Particular methods comprise the administration of a tryptophan hydroxylase inhibitor and at least one other active pharmaceutical ingredient to patient in need thereof. Pharmaceutical formulations are also disclosed.

Methods and compositions for treating pulmonary hypertension and related diseases and disorders

Methods and vectors (both DNA and retroviral) are provided for the construction of a Library of mutated cells. The Library will preferably contain mutations in essentially all genes present in the genome of the cells. The nature of the Library and the vectors allow for methods of screening for mutations in specific genes, and for gathering nucleotide sequence data from each mutated gene to provide a database of tagged gene sequences. Such a database provides a means to access the individual mutant cell clones contained in the Library. The invention includes the described Library, methods of making the same, and vectors used to construct the Library. Methods are also provided for accessing individual parts of the Library either by sequence or by pooling and screening. The invention also provides for the generation of non-human transgenic animals which are mutant for specific genes as isolated and generated from the cells of the Library.

Vectors for making genomic modifications

Novel human ATP binding cassette transporter polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.

Polynucleotides encoding human transporter proteins

The nucleotide and corresponding amino acid sequences are reported for a novel class of mammalian lipoxygenase proteins. The novel lipoxygenase encoding polynucleotides were obtained from human gene trap clones and human cDNA libraries.

Lipoxygenase proteins and polynucleotides encoding the same

The present invention relates to methods and compositions for the treatment of biological disorders regulatable by the controlled expression or inhibition of the described uncoupling proteins (UCPs).

Human uncoupling proteins and polynucleotides encoding the same

Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.

Human transferase proteins and polynucleotides encoding the same

Human ATPase proteins and polynucleotides encoding the same

Human proteases and polynucleotides encoding the same

Methods and vectors (both DNA and retroviral) are provided for the construction of a Library of mutated cells. The Library will preferably contain mutations in essentially all genes present in the gene of the cells. The nature of the Library and the vectors allow for methods of screening for mutations in specific genes, and for gathering nucleotide sequence data from each mutated gene to provide a database of tagged gene sequences. Such a database provides a means to access the individual mutant cell clones contained in the Library. The invention includes the described Library, methods of making the same, and vectors used to construct the Library. Methods are also provided for accessing individual parts of the Library either by sequence or by pooling and screening. The invention also provides for the generation of non-human transgenic animals which are mutant for specific genes as isolated and generated from the cells of the Library.

Indexed library of cells containing genomic modifications and methods of making and utilizing the same

Human endothelin converting enzyme-like proteins and polynucleotides encoding the same

Novel vectors are described that incorporate, inter alia, a novel 3&prime; gene trap cassette that does not encode a marker conferring antibiotic resistance and which can be used to efficiently trap, mutagenize, and identify previously unknown cellular genes. Vectors incorporating the presently described 3&prime; gene trap cassette find particular application in gene discovery, and the production of mutated cells and animals.

Vectors for gene mutagenesis and gene discovery

The present invention relates to LDLPs, nucleotides encoding the same, and methods and compositions for the treatment of biological disorders regulatable by the controlled expression, binding, and/or inhibition of the described LDLPs.

Human LDL receptor encoding polynucleotides

Human kinase proteins and polynucleotides encoding the same

Growing community of inventors

The Woodlands, TX, United States of America

Arthur T Sands