University of Florida Research Foundation, Incorporated

Arthur Rick Alleman

Anthony F Barbet

Michael John Burridge

Travis C McGuire

Roman Reddy Ganta

Suman M Mahan

Michael V Bowie

Fred R Rurangirwa

William M Whitmire

Bigboy H Simbi

Annie L Moreland

Aceme Nyika

We have successfully sequenced and cloned the gene expressing the Major Surface Protein 5 (MSP5) of. The recombinant MSP5 (rMSP5) protein has been tested using sera from humans and dogs infected with. The polypeptide has been found to be immunogenic and useful as a diagnostic test antigen. The polypeptide antigen of the subject invention can provide the basis of a diagnostic assay that would allow the rapid, in-house, laboratory diagnosis of infection withusing a sample (e.g., serum, plasma, or whole blood) from an infected human or animal. Additionally, the subject invention provides methods of detecting the presence ofin biological or environmental samples utilizing antibodies provided by the subject invention. Furthermore, the use of the single antigen in the diagnosis of this important disease offers many advantages including enhanced test specificity, ease of testing and consistency of results using synthetically produced test antigens instead of cultured, whole organisms.

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Described are nucleic acid vaccines containing genes to protect animals or humans against rickettsial diseases. Also described are polypeptides and methods of using these polypeptides to detect antibodies to pathogens.

Nucleic acid vaccines against rickettsial diseases and methods of use

Described are nucleric acid vaccines containing genes to protect animals or humans against,. Also described are polypeptides and methods of using these polypeptides to detect antibodies to pathogens.

Nucleic acid vaccines for ehrlichia chaffeensis and methods of use

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Alachua, FL, United States of America

Arthur Rick Alleman