Burroughs Wellcome Co.

Arthur P Phillips

John D McDermed

Richard M Welch

Alan R Brown

Gerald M McKenzie

The present invention is concerned with the compound of formula (I) ##STR1## and its acid addition salts. The invention is also directed to the use of the compound of formula (I) and its pharmaceutically acceptable acid addition salts as positive conotropic agents in mammals.

Quinoline compound

The present invention is concerned with the compound of formula (I) ##STR1## and esters and acid addition salts thereof having positive inotrope effect.

6-(4-hydroxypiperidino) carboslyril

6-piperidyl carbostyril compounds and compositions containing them

A compound of the formula (I) may be prepared by known methods and may be used in the treatment of pain, inflammation or pyresis in mammals, by administration of the compound alone or in a pharmaceutical formulation suitable for administration to a mammal in need thereof. ##STR1##

Topical inflammatory pharmaceutical formulations

A radioimmunoassay procedure has been discovered for bupropion [(.+-.)-2-t-butylamino-3-chloropropiophenone], an antidepressant compound, in biological fluids. Novel compounds of formula ##STR1## wherein either R.sub.2 is oxygen and R.sub.1 is (CH.sub.2).sub.n --O--(CO).sub.m --(CH.sub.2).sub.p --COOH where n is an integer from 0 to 5, m is 0 or 1, and p is an integer from 1 to 4; or R.sub.1 is hydrogen and R.sub.2 is N--O--(CH.sub.2).sub.q --COOH where q is an integer from 1 to 3, and novel methods of making them and novel intermediates useful therein are disclosed. Novel immunogens for raising bupropion specific antisera, and novel methods of making them are disclosed comprising conjugates of the novel compounds and suitable carrier material. The drug is added to the antisera together with novel radiolabeled competitor of formula ##STR2## wherein R' is a suitable radioisotope as described above and R.sub.3 is hydrogen, R.sub.4 is Cl, and R.sub.5 is oxygen, or

Compounds and methods of making them

5,6-Dialkoxy-2-tetralones (I) are disclosed as useful intermediates in the synthesis of 2-amino-5,6-dialkoxytetralins (III) and 2-amino-5,6-dihydroxytetralins (IV). Compounds of the groups III and IV are potent emetics.

Growing community of inventors

Raleigh, NC, United States of America

Arthur P Phillips