Syntex (u.s.a.) Inc.

Other

Arthur M Strosberg

Arthur F Kluge

George A Christie

Roger Whiting

Robin D Clark

Roger L Whiting

Stefan H Unger

Jean-Claude G Pascal

Novel compounds of the general formula ##STR1## and the pharmaceutically acceptable esters and acid addition salts thereof, wherein:

Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl

Novel compounds of the general formula: ##STR1## and the pharmaceutically acceptable esters and acid addition salts thereof, wherein:

Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect

2-(1,4-Benzodioxan-2-ylalkyl)imidazoles having the general formula: ##STR1## wherein R.sup.1, and R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen, and alkyl (1-6C), and wherein n is an integer equal to 0, 1 or 2, and the pharmaceutically acceptable acid addition salts thereof, are .alpha..sub.2 blockers and thus are useful as affectors of the CNS, specifically as platelet aggregation inhibitors and as antihypertensives.

2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antihypertensives and

Compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein:

Benzodioxane-imidazoline compounds as antihypertensives

2-(1,4-Benzodioxan-2-ylalkyl)imidazoles having the general formula ##STR1## wherein R.sup.1 and R.sup.2 are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted phenyl, and optionally substituted phenyl lower alkyl;

2-(1,4-Benzodioxan-2-ylalkyl)imidazoles

2-(1,4-Benzodioxan-2-ylalkyl)imidazoles having the general formula: ##STR1## wherein R.sup.1, and R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen, and alkyl, and wherein n is an integer equal to 0, 1 or 2, and the pharmaceutically acceptable acid addition salts thereof, are useful as antidepressants.

2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants

Compounds of the formula ##STR1## and the pharmaceutically acceptable, non-toxic salts thereof, wherein: R is hydrogen, lower alkyl, or benzyl;

2-(1,4-Benzodioxan-2-ylalkyl)benzimidazoles useful as anti-depressants

Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are the same or different and are hydrogen, C.sub.1 to C.sub.6 alkyl, C.sub.6 to C.sub.12 carbocyclic aryl or aralkyl of 1 to 6 carbon atoms in the alkyl moiety and 6 to 12 carbon atoms in the carbocyclic aryl moiety;

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Portola Valley, CA, United States of America

Arthur M Strosberg