Merck + Co., Inc.

Interpore Orthopaedics, Inc.

Exogen, Inc.

Meditron Corporation

Arthur L Lifshey

Roger J Talish

The present invention is directed to a dual compartment, mixing and dispensing device suitable for the containment of two separate pharmaceutical components that mixable, upon breaking of a seal that separates the compartments, to provide an instantly mixed dose of medication. The medication can be administered to a patient through an aperture located at one end of the device. The device is characterized as two compartments connected by a flexible, sealed orifice, wherein the two components are separated. Flexing of the device at the orifice breaks the seal and allows mixing of the components to prepare the dose. Thereafter, an end-portion of the device can be opened for oral administration of the dose.

Dual compartment mixing and dispensing device

An improved process of creating a uniform puncture in a medication dispenser bottle utilizes a membrane within the tip of the dispenser which is punctured with the hole being of a controlled, uniform size. The size of the hole is controlled by a mechanical stop created by shoulders integral to the base of the puncturing member.

Flow control orifice

A process of welding plastic vials and closure suitable for sterile filling operations is disclosed. Following a mechanical seal, a heated die is used to fuse the container and closure into a hermetic seal capable of use in the pharmaceutical industry.

Welding process

Combined dispenser and cap

A closure device for containers comprising a cap having a piercing member, the cap moving first downward and then upward relative to a container to which it is affixed, when first rotated in the direction used to open the container, the piercing member capable of causing rupture of a seal on the container during the downward motion and the upward motion resulting in removal of the cap.

Piercing container cap

The invention relates to methods and apparatus for locating an internal injury. The apparatus includes a marker that is temporarily positionable at an external location adjacent the internal injury. The marker is formed of a material that is visible on an X-ray, magnetic resonance image, ultrasonic image, or other device for imaging the internal injury. The method includes the steps of positioning a marker at an external location adjacent an internal injury, simultaneously visualizing the marker and the internal injury, and marking an approximate external location corresponding to the internal injury. Where X-rays are used for simultaneously visualizing the marker and the internal injury, the X-ray is used to map the approximate external location corresponding to the internal injury.

Locator method and apparatus

This invention consists of an ophthalmic storage and dispensing device formed by injection molding, consisting of a vial with thick rigid walls and a limited flexible area. The flexible area allows only a small displacement when squeezed providing a metered volume of dispensed liquid. It also has an integral molded dropper tip as well as an integral molded puncture membrane within the tip. A bottom plug, which serves as closure after filling, is sealed to the vial. The bottom plug is of varying size and shape so as to provide for varying internal liquid capacity in the same bottle. It can also have a separate cap which acts as both a seal break and reclosable mechanical liquid seal between usage periods. Both vial and cap offer a geometric shape which facilitates gripping and limits rolling.

Ophthalmic package and delivery device

This invention consists of an ophthalmic dispensing tip formed by injection molding, which has a one-piece molded tip to be used with a mating cap, the tip having an internally molded breakaway barrier membrane inside the flow channel, and the cap having a shaped stud fitting inside the tip, so that the final clockwise half-turn of the cap pushes the stud against the barrier and displaces it, thereby creating a restricted path through which the contents are dispensed.

Non-streaming ophthalmic tip and delivery device

Single use fluid dispensing container

A flexible fluid dispensing bottle is provided which conveniently meters out its contents in several small controlled doses. The device is designed to specifically provide multiple extended outlets to facilitate access beneath the fur of an animal ('comb effect') and to better spread treatment. In addition, the device uses a combination of bottle geometry, and internal ribs and cores to control capacity as well as volume displaced during individual pump strokes of the squeeze bottle.

Single use fluid dispensing device

A device for the subcutaneous implantation of a pharmaceutical dosage form is presented. The device includes a cannula which houses the pharmaceutical dosage form and push member, all of which are prepackaged and may be sterilized. The device further includes an actuator comprising a flexible stylet, a trigger and a handle.

Device for injecting implants

The invention contemplates an improved strap or bandage mounting of a socket element for removably engaged coupling of an ultrasonic transducer element to an afflicted limb. In a preferred embodiment, a radially flanged annular socket element is formed with outward lugs at axial offset from the flange, for preliminary assembly to a length of bandage material which has been cut to provide an opening for registration with the bore of the socket element, with the flange surrounding the opening and against one side of the bandage, while the outward lugs engage the other side of the bandage and also assure the desired registration. A softly compliant pad having a similar opening is removably securable to the flange-mounted side of the bandage to hold registration of the same central opening for all components and to afford direct access to an afflicted body-limb region through the central opening, when the thus-assembled bandage has been wrapped around the limb to securely position the socket element for reception of the transducer of a treatment head. Bayonet-locking lug formations on or near the transducer part of the head coact with lug formations on the socket element to retain the transducer during treatment of an afflicted bone through gel-coupled flesh at the situs of injury.

Ultrasonic orthopedic treatment head and body-mounting means therefor

The invention contemplates an improved body-applicator unit forming a component of an ultrasonic bone-therapy system exemplified by the disclosure of copending patent application Ser. No. 247,105, filed Sep. 14, 1988 now. U.S. Pat. No. 5,003,965. The improvement features transducer suspension from the rest of the applicator unit via a molded sylphon-bellows element of softly compliant elastomeric material, wherein the transducer is a flat disc, retained as the outer closure wall of the elastomeric bellows, in such manner as to be surrounded by a flexible gel-retaining circumferential lip formation of the bellows.

Ultrasonic transducer device for treatment of living tissue and/or cells

The invention contemplates an ultrasonic body treatment system wherein a body applicator is self-contained unit with its own radio-frequency oscillator/driver, factory-pretuned to its own transducer. A remote-control unit supplies control signals via optical coupling to the oscillator-driver of the body-applicator unit. Another optical coupling from the body-applicator unit to the remote-control unit enables fidelity of applicator performance to be monitored at the remote-control unit. A safety interlock at the body-applicator unit precludes transducer operation in the absence of adequate coupling to a patient's body. The remote-control unit can thus provide all supervisory and control functions for the body-applicator unit without any electrical interconnection between these units.

Growing community of inventors

East Brunswick, NJ, United States of America

Arthur L Lifshey