E.i. Dupont De Nemours and Company

Other

Arthur John Elliott

William J O'Donnell

Paul Mazzell, Jr

Lee Grant Sprague

Elena M Bingham

A process for preparing isoflurane (1-chloro-2,2,2-trifluoroethyl difluoromethyl ether) by reacting PFE (2,2,2-trifluoroethyl difluoromethyl ether) with chlorine in the presence of ultraviolet light and added water, at a low temperature and/or at a high conversion.

Preparation of isoflurane by reaction of 2,2,2-trifluoroethyl difluoro-methyl ether and chlorine in added water, at low temperatures and/or at higher conversions

1-Methyl-6-substituted-4-phenyl-quinazolin-2-one-3-oxides and their use as intermediates in the preparation of 3-fluorobenzodiazepines which are useful as tranquilizers, muscle relaxants and sedatives.

Quinazolinone oxides and their use as intermediates for pharmaceutical

Compounds are provided which have the formula: ##STR1## WHERE Ar.sup.1 and Ar.sup.2 are aromatic radicals and X and Y are 1 to 2 nitrogen atoms and conversely 3 to 2 carbon atoms which may have selected substitutes. Preferably, 2 adjacent carbon atoms (usually the 2 Y's) have a butadienyl or a substituted butadienyl attached thereto. The compounds are useful as dyes.

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New Castle, DE, United States of America

Arthur John Elliott