Schering Corporation

Halocarbon Products Corporation

Arthur J Elliott

Raymond G Lovey

Elijah H Gold

Joel G Berger

Wei K Chang

Gary W Astrologes

Substituted 8-amino-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines useful in treating mental disorders and which have activities of prolonged duration are disclosed. Methods for preparing these compounds and methods for their use are also described.

1,2,4,5 tetrahydro benzazepine-3 compounds and antipsychotic use thereof

Novel compounds including 1-aryl-1-(1H-imidazol-1-ylmethyl)-1,3-dihydroisobenzofurans such as 1-(4-chlorophenyl)-1-(1H-imidazol-1-ylmethyl)-1,3-dihydroisobenzofuran, and 1-aryl-1-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dihydroisobenzofurans are disclosed. The corresponding benzo[c]thiophenes, isochromans, and isothiochromans and antifungal pharmaceutical compositions containing same, and methods of using said pharmaceutical compositions to elicit an antifungal response in warm blooded animals having a susceptible antifungal infection are also disclosed.

1-Aryl-1-(1H-azol-1-ylalkyl)-1,3-dihydroisobenzofurans, related

Novel compounds including 1-aryl-1-(1H-imidazol-1-ylmethyl)-1,3-dihydroisobenzofurans such as 1-(4-chlorophenyl)-1-(1H-imidazol-1-ylmethyl)-1,3-dihydroisobenzofuran, and 1-aryl-1-(1H-1,2,4-trizazol-1-ylmethyl)-1,3-dihydroisobenzofurans are disclosed. The corresponding benzo[c]thiopenes, isochromans, and isothiochromans and antifungal pharmaceutical compositions containing same, and methods of using said pharmaceutical compositions to elicit an antifungal response in warm blooded animals having a susceptible antifungal infection are also disclosed.

1-aryl-1-(1H-azol-1-ylalkyl)-1,3-dihydroisobenzofurans, related

A process for the coupling of a chloroperfluoroalkane having a --CFCl.sub.2 moiety which comprises heating the alkane at a temperature of about 150.degree. to 260.degree. C. in the presence of at least about 0.1 times the molar amount each of copper and zinc at a mole ratio of copper:zinc from about 2:1 to 1:2. The product is obtained in relatively high yield and conversion.

Coupling of chloroperfluoroalkanes

In the reaction of a 2,2,2-trifluoroethyl halide with ammonia to produce 2,2,2-trifluoroethylamine, the improvement which comprises effecting the reaction with from about 1 to 3 moles of ammonia per mole of the trifluoroethyl halide at a temperature of about 170.degree. to 240.degree. C. and a pressure less than about 300 psig in the presence of a substantially anhydrous inert solvent present in at least about the same molar amount as the trifluoroethyl halide. Advantageously the temperature is from about 200.degree. to 220.degree. C., the pressure is at most about 250 psig, the solvent is N-methylpyrrolidone present in at least about 3 times the molar amount of the trifluoroethyl halide, and the halide is the chloride.

Growing community of inventors

Sloatsburg, NY, United States of America

Arthur J Elliott