Focal, Inc.

Semprus Biosciences Corporation

Genzyme Corporation

Other

The University of Texas System

Arrow International Limited

The University of Arizona

Strait Access Technologies Holdings (pty) Limited

Entrega Inc.

Arthur J Coury

Amarpreet S Sawhney

Luis Z Avila

Chandrashekhar Prabhakar Pathak

Jeffrey Alan Hubbell

Zheng Zhang

Jun Li

Mark T Kieras

Stephen D Goodrich

Stephen Jack Herman

David A Melanson

Carlo Giovanni Traverso

Shikha P Barman

Christopher R Loose

Peter K Jarrett

Ronald S Rudowsky

C Michael Philbrook

Douglas J Weaver

Chad Cori Huval

Patrick K Campbell

Laurence A Roth

Michael A Bouchard

Kevin M Berrigan

Fei Yao

David J Enscore

George E Selecman

Dean M Pichon

David J Nedder

Bradley C Poff

Karen Ann Schultz

Donald L Elbert

Matt Skinner

John C Spiridigliozzi

Marvin J Slepian

Hao Wang

Deon Bezuidenhout

Thomas Bromander

Donald Leo Elbert

Thomas Henry Jozefiak

Colin R Gardner

Michelle D Lyman

Hildegard M Kramer

Thomas S Bromander

Chandrashekar P Pathak

William C Nason

Michelle D Powell

Alonzo Cook

Douglas J K Weaver

Marc A Levine

Keith Baker

Johan Coetzee

Jandré De Villiers

Jeffrey A Hubbell

Ayush Verma

Eric W Marchese

John F Traverse

Abby N Deleault

David Gideon Conradie

Douglas Weaver

David Lucchino

B Andre′ Weinstock

Linda M Guiney

Phu C Nguyen

Andrew Craig Miller

John Jantz

B Andre Weinstock

Li Jun

Daniel Bonner

Peter Tran

Michael Bouchard

Douglas JK Weaver

Polymers having mechanical properties approaching or exceeding commercial elastomers and engineering thermoplastics, but improved biostability, are described herein. In one embodiment, the polymers have a hard segment containing one or more disulfoxide or disulfone moieties and a soft segment connected to the hard segment to form an elastomeric polymer. The polymer is resistant to oxidation and/or hydrolytic degradation, particularly in vivo, which allows for the use of these materials in implants/devices which are implanted for an extended period of time. The ratio or percentage by weight of soft segment to hard segment can be varied based on the physical and mechanical properties of the desired device.

Biostable segmented elastomers and thermoplastics and methods of making and using thereof

Partially crosslinked polyurethane polymers comprising diisocyanates and aliphatic hydrocarbon soft segments with a short-chain diol chain extender and a multifunctional amine and/or alcohol crosslinker to provide a polyurethane polymer with useful properties for the production of medical implant devices such as heart valves, are described. The polymers have an unexpected linear elastic region in a range from 5-100% and preferably between 10-35%. In some embodiments the polyurethanes are a thermally convertible gel formulation which may be converted to a liquid formulation by extended heating to render the polymer suitable for solvent processing techniques such as casting, spraying, spinning, etc. The invention also provides for living hinge polyurethane polymers which are thermally modifiable from a gel to a liquid and reaction injection moulded (RIM) polyurethanes with an enhanced flex life.

Polyurethanes

A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cmin a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37&#xb0; C. in 70 &#x3bc;g/mL fibrinogen derived from human plasma containing 1.4 &#x3bc;g/mL I-125 radiolabeled fibrinogen.

Non-fouling, anti-microbial, anti-thrombogenic graft-from compositions

The present invention generally relates to articles of manufacture, such as medical devices, having a non-fouling surface comprising a grafted polymer material. The surface resists the adhesion of biological material.

Non-fouling, anti-microbial, anti-thrombogenic graft compositions

Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described.

Redox processes for contact lens modification

Surface modified contact lenses

Multistep UV process to create surface modified contact lenses

Silicone hydrogel contact lens modified using lanthanide or transition metal oxidants

Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.

Articles having non-fouling surfaces and processes for preparing the same without altering bulk physical properties

Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.

Multiblock biodegradable hydrogels for drug delivery and tissue treatment

Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and methods of preparation and use thereof are described. The macromers are preferably polymerized using free radical initiators under the influence of long wavelength ultraviolet light or visible light excitation. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. The macromers can be used to encapsulate cells, deliver prophylactic, therapeutic or diagnostic agents in a controlled manner, plug leaks in tissue, prevent adhesion formation after surgical procedures, temporarily protect or separate tissue surfaces, and adhere or seal tissues together.

Polymerizable biodegradable polymers including carbonate or dioxanone linkages

Hydrogels intended for orthopedic applications, including repair and regeneration of cartilage, bone, joint surfaces and related tissues, must possess greater strength and toughness than hydrogels used in soft tissue repair. A hydrogel formulation is provided which has high strength, toughness, a suitable mechanical modulus and low equilibrium hydration. It may also have controlled porosity or degradation time. It can be made to polymerize in situ with high ('good' to 'excellent') adherence to target tissue or surfaces. A preferred formulation for forming such gels comprises 40 to 80% by weight of a low-molecular weight polar monomer and 30 to 10% of a hydrophilic macromeric crosslinker.

Hydrogels for orthopedic repair

SOD and other active oxygen inhibitors are directly applied in combination with a barrier material at local sites of tissue injury to prevent or decrease formation of adhesions and undesirable proliferation of cells. Preferred barrier materials are polymeric hydrogels providing controlled release of AOI which are directly applied to the afflicted tissue. Examples demonstrate the effects of SOD on pelvic adhesions in the rat when administered by intraperitoneal (I.P.) bolus and by localized sustained release from a topically applied hydrogel system.

Reduction of adhesions using controlled delivery of active oxygen inhibitors

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Boston, MA, United States of America

Arthur J Coury